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Prognostic Value Of Short-Term Follow-up Biomarkers After Discharge In hOspitalized Patients With Acute Heart Failure

Study acronym: POSTBIO-HF
StatusRecruiting
PhaseNot specified
Started2021-02-01
View on ClinicalTrials.gov ↗
Record status
This record was last updated September 19, 2024 (before its estimated December 31, 2024 completion). Its status may not reflect the trial's current state.

Amendment history

2024-09-06
Study Status, Sponsor/Collaborators v5
Collaborators1 entry, revised
Roche Diagnosticsdiagnostics GmbHKorea
2024-08-12
Study Status, Sponsor/Collaborators v4
Primary completion date2023-12-31→2024-12-31
Collaborators1 entry, revised
Roche PharmaDiagnostics AGGmbH
2023-07-30
Study Status v3
Re-verified, no change to tracked fields
2021-05-12
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v2
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2020-10-01→confirmed 2021-02-01
Study sites0→1
2020-09-08
Study Status, Study Description, Outcome Measures, Eligibility v1
Start date2020-07-01→2020-10-01
Eligibility criteria+69 characters
[...] f HF b) elevated levels of natriuretic peptides (defined as B-type natriuretic peptide (BNP) >100pg/ml and/or N terminal B-type natriuretic peptide (NT-proBNP) >300pg/ml) c) any structural heart disease (left atrial vol [...]
Secondary endpoints6 entries, revised
AllThe incidence rate (%) of all cause mortality CardiovascularThe incidence rate (%) of cardiovascular mortality HospitalThe incidence rate (%) of hospital readmission HospitalThe incidence rate (%) of hospital readmission due to heart failure aggravation CerebrovascularThe incidence rate (%) of cerebrovascular events AcuteThe incidence rate (%) of acute coronary syndrome
Primary endpoints1 entry, revised
CardiovascularThe incidence rate (%) of composite endpoint including cardiovascular mortality or hospital readmission
2020-06-16
Original filing
Several surrogate biomarkers including natriuretic peptide(NP), and growth differentiation factor-15(GDF-15) and ST2 has prognostic significance in heart failure(HF), and reductions in its value may predict clinical improvement. However, there are limited data regarding the prognostic value of these biomarkers during short-term follow-up after discharge in acute decompensated heart failure. The purpose of this study is to evaluate the prognostic value of short-term follow-up surrogate biomarkers for predicting prognosis of hospitalized patients with acute decompensated heart failure.
Trial Details
NCT Number NCT04437628
Lead Sponsor Wonju Severance Christian Hospital
Collaborators: Roche diagnostics Korea
Conditions Heart Failure
Enrollment 1,500 participants
Start Date 2021-02-01
Primary Completion 2024-12-31 (estimated)
Study Completion 2025-12-31 (estimated)
Updated on ClinicalTrials.gov 2024-09-19