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Study of Circulating Monocytes in Patients With Ischemic Vascular Disease

StatusRecruiting
PhaseNot specified
Started
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Record History

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  1. Site contact updatedv6
  2. Primary and study completion dates: Feb 1, 2025 to Dec 1, 2027v5
  3. Primary and study completion dates: Feb 1, 2022 to Feb 1, 2025
    • Site contact updated
    v4
  4. Start date: Feb 1, 2013 to Dec 1, 2013
    • Primary and study completion dates: Feb 2022 to Feb 1, 2022
    • Study description revised
    v3
  5. Primary endpoint revised
    • Study description expanded, about 4 words
    v2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
UConn Health
38 trials monitored
See 2 trials at risk
Heart Disease
8,786 trials monitored
See 412 trials at risk
Stroke
3,531 trials monitored
See 153 trials at risk
The purpose of this research study is to discover the functions of circulating white blood cells, called monocytes, and associated circulating substances in heart attack and ischemic stroke patients. Ischemic Strokes (clots) occur as a result of an obstruction within a blood vessel supplying blood to the brain. A type of monocyte carrying a surface marker called "P2X4" helps the immune system sense and respond to danger signals from the body such as heart muscle and brain tissue injuries. The researchers expect to learn more about how these monocyte cells react to heart and brain tissue injury, and how the cells may then produce proteins or other chemical substances which promote the healing of heart muscle after heart attack and brain tissue after an ischemic stroke.
Trial Details
NCT Number NCT04321512
Lead Sponsor UConn Health
Conditions
(from sponsor)		 Myocardial Infarction, Stroke, Ischemic, Ischemia
Related terms Ischemia, Ischemic Stroke, Myocardial Infarction
Enrollment 300 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov