Clinical Trial

Study of Circulating Monocytes in Patients With Ischemic Vascular Disease

Recruiting
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Summary
The purpose of this research study is to discover the functions of circulating white blood cells, called monocytes, and associated circulating substances in heart attack and ischemic stroke patients. Ischemic Strokes (clots) occur as a result of an obstruction within a blood vessel supplying blood to the brain. A type of monocyte carrying a surface marker called "P2X4" helps the immune system sense and respond to danger signals from the body such as heart muscle and brain tissue injuries. The researchers expect to learn more about how these monocyte cells react to heart and brain tissue injury, and how the cells may then produce proteins or other chemical substances which promote the healing of heart muscle after heart attack and brain tissue after an ischemic stroke.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2020-03-23; most recent amendment 2025-08-10.
Trial Details
NCT Number NCT04321512
Lead Sponsor UConn Health
Conditions Myocardial Infarction, Stroke, Ischemic, Ischemia
Enrollment 300 participants
Start Date 2013-12-01
Primary Completion 2027-12-01 (estimated)
Study Completion 2027-12-01 (estimated)
Updated on ClinicalTrials.gov 2025-08-14