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NCT04261712 · ClinicalTrials.gov record · last posted 2026-07-29

A Study to Evaluate the Long-Term Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Advance)

StatusTerminated
PhasePhase 2
Started2020-01-29
View on ClinicalTrials.gov ↗
Why the trial stopped
The study was stopped early for business reasons (not due to changes in the benefits or risks of paltusotine).
from the ClinicalTrials.gov record
A phase 2, open label, long-term extension study designed to evaluate the safety and efficacy of paltusotine (formerly CRN00808; an oral selective nonpeptide somatostatin receptor type 2 biased agonist) in subjects with acromegaly.

Protocol amendment history 6 changes detected by DataLookout

2026-07-30
Trial terminated
2026-07-30
Trial terminated: The study was stopped early for business reasons (not due to changes in the benefits or risks of paltusotine).
2026-07-30
Primary completion moved earlier: 2028-03-31 → 2026-06-30
2026-07-30
Completion moved earlier: 2028-03-31 → 2026-06-30
2026-07-09
Primary completion pushed: 2028-03 → 2028-03-31
2026-07-09
Completion pushed: 2028-03 → 2028-03-31
Trial Details
NCT Number NCT04261712
Lead Sponsor Crinetics Pharmaceuticals Inc.
Conditions Acromegaly
Enrollment 43 participants
Start Date 2020-01-29
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-07-29