Clinical Trial

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Recruiting
View on ClinicalTrials.gov →
Summary
This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1 mutations.
Protocol Amendment History 1 change
notable Trial sites expanded: 549 -> 574 locations 2026-08-08
Trial Details
NCT Number NCT04251052
Lead Sponsor NRG Oncology
Collaborators: National Cancer Institute (NCI)
Conditions Ovarian Carcinoma
Enrollment 1,956 participants
Start Date 2020-09-01
Primary Completion 2047-06-30 (estimated)
Study Completion 2047-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-07