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Hypofractionated Whole-Pelvis Radiotherapy (WPRT) vs Conventionally-Fractionated WPRT in Prostate Cancer

Study acronym: HOPE
StatusActive, Not Recruiting
PhasePhase 2
Started2020-02-07
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 41 months later across 2 updates Mar 2024 → Sep 2027
See other at-risk trials from London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Amendment history

2026-10-02
Primary completion pushed: 2026-09 → 2027-09
Completion pushed: 2027-03 → 2028-03
2026-07-31
Study Status v7
Primary completion pushed: 2024-03 → 2026-09
2023-08-16
Study Status v6
Primary completion date2023-03→2024-03
2022-04-12
Recruiting→Active, Not Recruiting Study Status, Contacts/Locations v5
Trial statusRecruiting→Active, Not Recruiting
Study sitesdetails revised at 3 of 3 sites
2021-08-27
Study Status, Contacts/Locations v4
Study sites2→3
Show 3 earlier versions
2021-08-24
Study Status, Contacts/Locations v3
Study sites1→2
2021-02-25
Study Status v2
Re-verified, no change to tracked fields
2020-02-13
Not Yet Recruiting→Recruiting Study Status, Outcome Measures, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2020-01→confirmed 2020-02-07
Study sites0→1
Secondary endpoints16 entries, revised
Quality of Life - acute urinary and sexual QOL as measured by the EPIC-26 questionnaire Quality of Life - acute bowel toxicity as measured by the EPIC-Bowel Summaryquestionnaire Quality of Life - late bowel bother as measured by the EPIC- Bowel Summaryquestionnaire Quality of Life - late urinary and sexual QOL as measured by the EPIC-26 questionnaire
Primary endpoints1 entry, revised
Quality of Life (QOL) - late bowel function as measured by the EPIC- Bowel Summaryquestionnaire
2019-12-11
Original filing
The purpose of this research study is to determine if 5 (five) fractions of external radiotherapy with higher radiation doses per fraction to the pelvis leads to similar results to the standard of care external radiotherapy treatment that is comprised of 25 fractions of external radiotherapy with lower radiation doses per fraction to the pelvis. This study aims to investigate the impact in quality of life associated with hypofractionated Whole Pelvis Radiotherapy (WPRT) in comparison to conventionally-fractionated WPRT in patients with unfavorable-intermediate and high-risk prostate cancers. This information is valuable as hypofractionated WPRT is a more attractive and convenient treatment approach, and may become the new standard of care if proven to be well-tolerated and effective. Therefore, this study aims to provide a more rational justification for use of hypofractionated WPRT in future larger randomized trials by comparing this strategy with the current standard of care. This study will also provide an initial understanding of the toxicity profile and cancer control associated with hypofractionated WPRT and High Dose Rate Brachytherapy (HDR-BT).
Trial Details
NCT Number NCT04197141
Lead Sponsor London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Collaborators: Canadian Association of Radiation Oncology, AbbVie
Conditions Prostate Cancer
Enrollment 58 participants
Start Date 2020-02-07
Primary Completion 2027-09 (estimated)
Study Completion 2028-03 (estimated)
Updated on ClinicalTrials.gov 2026-10-01