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Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment

Study acronym: CSA
StatusRecruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 6 months later Jun 30, 2026 → Dec 31, 2026
See other at-risk trials from VA Office of Research and Development

Record History

  1. Primary completion pushed from Jun 30, 2026 to Dec 31, 2026 Completion pushed from Dec 31, 2026 to Jun 30, 2027 · Study description expanded, about 2 wordsv15 Show 2 more changesShow less
    • Completion pushed from Dec 31, 2026 to Jun 30, 2027
    • Study description expanded, about 2 words

    See this version in full on ClinicalTrials.gov ↗

  2. Re-verified, no change to tracked fieldsv14
  3. Primary completion date: Jun 30, 2025 to Jun 30, 2026 Completion date: Dec 31, 2025 to Dec 31, 2026v13 Show 1 more changeShow less
    • Completion date: Dec 31, 2025 to Dec 31, 2026
  4. Primary completion date: Jun 28, 2024 to Jun 30, 2025 Completion date: Dec 31, 2024 to Dec 31, 2025v12 Show 1 more changeShow less
    • Completion date: Dec 31, 2024 to Dec 31, 2025
  5. Primary completion date: May 31, 2023 to Jun 28, 2024 Site details revisedv11 Show 1 more changeShow less
    • Site details revised
Show 9 earlier versionsHide 9 earlier versions
  1. Re-verified, no change to tracked fieldsv10
  2. Completion date: Nov 30, 2023 to Dec 31, 2024v9
  3. Trial status: Not Yet Recruiting to Recruiting Start date changed from estimate of Dec 4, 2020 to Jan 7, 2021 · Site details revisedv8 Show 2 more changesShow less
    • Start date changed from estimate of Dec 4, 2020 to Jan 7, 2021
    • Site details revised
  4. Start date: Oct 30, 2020 to Dec 4, 2020v7
  5. Start date: Aug 21, 2020 to Oct 30, 2020v6
  6. Start date: Jul 20, 2020 to Aug 21, 2020v5
  7. Start date: Jun 1, 2020 to Jul 20, 2020 Study description expanded, about 26 wordsv4 Show 1 more changeShow less
    • Study description expanded, about 26 words

    See this version in full on ClinicalTrials.gov ↗

  8. Start date: Apr 1, 2020 to Jun 1, 2020v3
  9. Re-verified, no change to tracked fieldsv2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions for central sleep apnea based on the strong premise that multi-modality therapy will normalize respiration and hence mitigate adverse long-term consequences of CSA. The investigators' proposed studies will test combination therapies, including positive airway pressure (PAP) plus a pharmacological agent who have heart failure or are using opioid analgesics. The investigators anticipate that findings will inform future clinical trials to improve care and quality of life among Veterans suffering from central sleep apnea, which remains difficult to treat using existing approaches.
Trial Details
NCT Number NCT04118387
Lead Sponsor VA Office of Research and Development
Conditions Sleep Disordered Breathing, Able Bodied
Enrollment 200 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov