Clinical Trial

Closed Loop Ventilation With High Tidal Volumes and Safe Transpulmonary Pressure in COPD (COPD-SAFE)

Study acronym: COPD-SAFE
Not Yet Recruiting
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Record status
This record was last updated October 15, 2024 (before its estimated February 2025 completion). Its status may not reflect the trial's current state.
Summary
This study evaluates the safety and efficacy of high tidal volumes generated by "Adapted Support Ventilation (ASV) mode' in mechanically ventilated severe COPD patients. Every patient will be ventilated consecutively with ASV and Volume Control (VC) modes at 2 different levels of minute volume in 2 sets. ASV mode is expected to be safe measured by adequate inspiratory transpulmonary pressures and expected to be as effective as VC mode with lower intrinsic positive end expiratory pressure (iPEEP) levels.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2019-09-12; most recent amendment 2024-10-12.
Trial Details
NCT Number NCT04089111
Lead Sponsor Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Conditions Chronic Obstructive Pulmonary Disease
Enrollment 20 participants
Start Date 2024-12
Primary Completion 2025-02 (estimated)
Study Completion 2025-02 (estimated)
Updated on ClinicalTrials.gov 2024-10-15