MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets

Brain metastases are a source of much morbidity and mortality in adults with primary solid malignant tumors. With improvements in systemic therapy that prolong survival but have limited central nervous system penetration, patients with brain metastases are at increasing risk of developing and experiencing long-term side effects from treatment of brain metastases. The overarching goal of this study is to better understand the determinants of RT-associated changes in white and gray matter function and associated neurocognitive decline.

NCT Number	NCT04073966
Lead Sponsor	UNC Lineberger Comprehensive Cancer Center
Conditions	Brain Metastases, Neurocognitive Deficit, White Matter Alterations, Radiation Exposure
Enrollment	20 participants
Start Date	2019-12-04
Primary Completion	2028-05-31 (estimated)
Study Completion	2029-05-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-14