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Troponin in Acute Chest Pain to Risk Stratify and Guide EffecTive Use of Computed Tomography Coronary Angiography

Study acronym: TARGET-CTCA
StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Start date: Sep 18, 2019 to Jan 31, 2026 Primary completion pushed from Feb 28, 2026 to Mar 31, 2026v12 Show 1 more changeShow less
    • Primary completion pushed from Feb 28, 2026 to Mar 31, 2026
  2. Completion date: Feb 28, 2026 to Aug 28, 2026v11
  3. Primary and study completion dates: Mar 31, 2025 to Feb 28, 2026v10
  4. Primary and study completion dates: Aug 31, 2024 to Mar 31, 2025v9
  5. Re-verified, no change to tracked fieldsv8
Show 6 earlier versionsHide 6 earlier versions
  1. Trial status: Recruiting to Active, Not Recruiting Primary and study completion dates: Aug 2024 to Aug 31, 2024 · Site details revised at 9 of 9 sitesv7 Show 2 more changesShow less
    • Primary and study completion dates: Aug 2024 to Aug 31, 2024
    • Site details revised at 9 of 9 sites
  2. Enrollment target: 2270 to 3170v6
  3. Primary and study completion dates: Nov 2023 to Aug 2024 Study sites: 2 to 9v5 Show 1 more changeShow less
    • Study sites: 2 to 9
  4. Re-verified, no change to tracked fieldsv4
  5. Trial status: Not Yet Recruiting to Recruiting Study sites: 0 to 2 · Start date changed from estimate of Aug 2019 to Sep 18, 2019 · Collaborators: 5 to 4v3 Show 3 more changesShow less
    • Study sites: 0 to 2
    • Start date changed from estimate of Aug 2019 to Sep 18, 2019
    • Collaborators: 5 to 4

    See this version in full on ClinicalTrials.gov ↗

  6. Eligibility criteria shortened, about 11 wordsv2 See this version in full on ClinicalTrials.gov ↗
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Most patients presenting to hospital with symptoms of a heart attack are sent home without further tests once a heart attack has been ruled out. Current strategies to assess patients with a suspected heart attack involve blood tests to measure troponin, a protein released into the bloodstream when the heart muscle is damaged. Despite having had a heart attack ruled-out, some patients have unrecognised heart disease and are at risk of having a heart attack in the future. However, clinicians do not know what is the best approach to identify and treat these patients. This study will use a heart scan known as computed tomography coronary angiogram (CTCA) to look for unrecognised heart disease in patients who have had a heart attack ruled out. In an earlier study, the Investigators performed this scan in patients referred to the outpatient cardiology clinic with stable chest pain and found that this improved the diagnosis of heart disease, leading to improvement in patient care that prevented future heart attacks. Previous research from the Investigators has also found that troponin levels below those used to diagnose a heart attack may help to identify those who are at greater risk of having a heart attack in the future. The aim of this study is to find out if patients with these low levels of troponin, where a heart attack has been ruled out, will benefit from CTCA to look for unrecognised coronary heart disease.
Trial Details
NCT Number NCT03952351
Lead Sponsor University of Edinburgh
Collaborators: British Heart Foundation, University of Sheffield, NHS Lothian, NHS Greater Glasgow and Clyde
Conditions Coronary Artery Disease
Enrollment 3,170 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov