Clinical Trial

EValuating the Safety Of De-escaLated Head and Neck Irradiation in HPV positivE Oropharynx Cancer in Non-smokers/Minimal Smokers

Active, Not Recruiting
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Record status
This record was last updated February 6, 2026 (before its estimated July 2026 completion). Its status may not reflect the trial's current state.
Summary
A prospective, observational study evaluating the durability of local/regional control of previously published de-escalated radiotherapy protocols for patients with P16 positive oropharynx cancers who have minimal nicotine exposure who are not current uses (\< 10 pack year smoking history; \< 10 year history of any nicotine product \[electronic cigarette, chewing tobacco\]). Quality of Life measures will also be collected.
Protocol Amendment History 9 amendments
This ClinicalTrials.gov record has been amended 9 times since 2018-12-13; most recent amendment 2026-02-03.
Status change: Recruiting → Active, Not Recruiting 2024-01-18
Status change: Active, Not Recruiting → Recruiting 2019-02-18
Trial Details
NCT Number NCT03777384
Lead Sponsor Sanford Health
Conditions Oropharyngeal Cancer
Enrollment 75 participants
Start Date 2018-10-12
Primary Completion 2026-07 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2026-02-06