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Safety of Blood Stem Cell Mobilization With Plerixafor in Patients With Sickle Cell Disease

Study acronym: PISMO
StatusActive, Not Recruiting
PhasePhase 1
Started2018-09-19
View on ClinicalTrials.gov ↗
The objective of this study is to investigate if up to two injections of plerixafor represent a safe and effective strategy to mobilize adequate numbers of CD34+ hematopoietic stem progenitor cells (HSPC) for autologous hematopoietic cell transplantation (HCT) in sickle cell disease (SCD) patients

Amendment history 2 changes detected by DataLookout

2026-09-03
critical
Primary completion pushed: 2026-08-03 → 2027-07-06
2026-09-03
minor
Completion pushed: 2026-08-03 → 2027-07-06
Trial Details
NCT Number NCT03664830
Lead Sponsor City of Hope Medical Center
Conditions Sickle Cell Disease
Enrollment 5 participants
Start Date 2018-09-19
Primary Completion 2027-07-06 (estimated)
Study Completion 2027-07-06 (estimated)
Updated on ClinicalTrials.gov 2026-09-02