Diesel Exhaust Induces Glucocorticoid Resistance

The investigators are studying the effects of exposure to diesel exhaust on lung inflammation in the presence and absence of an inhaled corticosteroid. Although data is mixed, studies show that asthmatics have increased lung inflammation and worse symptoms during periods of higher air pollution despite taking their anti-inflammatory corticosteroid medication. One possible reason is that air pollution exposure may decrease the ability of corticosteroids to combat inflammation. To test this volunteers will inhale either a placebo or a corticosteroid, before sitting in an exposure booth for 2 hours breathing either filtered air or diluted diesel exhaust. Samples will be collected before and after exposure to analyze the effects of budesonide and diesel exhaust exposure.

NCT Number	NCT03615742
Lead Sponsor	University of British Columbia Collaborators: Canadian Institutes of Health Research (CIHR), AllerGen NCE Inc.
Conditions	Exposure to Pollution, Glucocorticoid Resistance
Enrollment	30 participants
Start Date	2018-12-01
Primary Completion	2025-12-31 (estimated)
Study Completion	2025-12-31 (estimated)
Updated on ClinicalTrials.gov	2024-07-24