Application of ihMT MRI in Multiple Sclerosis

The development of in vivo biomarkers sensitive to myelin disruption represents a major clinical need to be able to monitor the demyelination processes as well as the effect of remyelinating therapies in multiple sclerosis. The investigators recently proposed a technique, derived from the conventional magnetisation transfer (MT): inhomogeneous Magnetisation Transfer (ihMT). In preliminary studies, this simple-to-implement and robust technique has shown great sensitivity for evaluating the demyelination processes. The goal of the project is to evaluate the ability of ihMT to measure and describe the spontaneous demyelination and remyelination processes involved in active lesions in a population of patients with MS at the the disease onset.

NCT Number	NCT03600779
Lead Sponsor	Assistance Publique Hopitaux De Marseille
Conditions	Sclerosis, Multiple
Enrollment	85 participants
Start Date	2018-06-14
Primary Completion	2027-08-14 (estimated)
Study Completion	2028-08-14 (estimated)
Updated on ClinicalTrials.gov	2026-08-06