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Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure

Study acronym: PREFER-HF
StatusRecruiting
PhaseNot specified
Started2016-04-07
View on ClinicalTrials.gov ↗
In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may develop and progress over time. We will evaluate distinct sub-groups of heart failure (also known as heart failure phenotypes) and cardiomyopathies including amyloidosis with an ultimate goal of bringing the right medications and therapy to the right patients to optimize benefit and minimized side effects, an effort to improve precision medicine in heart failure.

Amendment history 2 changes detected by DataLookout

2026-09-01
critical
Primary completion pushed: 2026-04-06 → 2028-10-31
2026-09-01
minor
Completion pushed: 2027-10-06 → 2028-12-31
Trial Details
NCT Number NCT03480633
Lead Sponsor Massachusetts General Hospital
Collaborators: Roche Diagnostics GmbH
Conditions Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Heart Failure, Right Sided, Heart Failure With Mid Range Ejection Fraction, Cardiovascular Risk Factor
Enrollment 3,000 participants
Start Date 2016-04-07
Primary Completion 2028-10-31 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-31