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Radiosurgical Hypophysectomy for Bone Metasteses Pain

StatusTerminated
PhaseNot applicable
Started2018-05-08
View on ClinicalTrials.gov ↗
Why the trial stopped
Accrual was slower than anticipated and funding was not extended beyond original contract.

Amendment history

2026-09-17
Results posted: 2026-09-16
2026-07-02
Study Status, Arms and Interventions, Outcome Measures, Document Section, Participant Flow, Baseline Characteristics, Outcome Measures (Results), Adverse Events, More Information v11
Secondary endpoints11 entries, revised
Rate of changeChange of diseaseDisease spreadSpread Participants With Reduction in Opioid Utilization Following Radiosurgical Hypophysectomy Rate of changeBiochemical inEndocrinopathy Participants opioidWith useRadiation Induced Optic Neuropathy Following Radiosurgical Hypophysectomy Participants With Radiation-associated Acute and Long Term Neurologic Toxicity Rate of biochemicalChange endocrinopathyof Insipidus Diabetes Rate of changeChange ofin optic nueropathyCosts Rate of changeChange of neurologic toxicityCortisol Rate of changeChange of insipidusPain diabetesWith Respect to Hormones Rat [...] [...]
Primary endpoints1 entry, revised
Change in Intensity of Bone Pain
2026-01-21
Recruiting→Terminated Study Status, Study Design, Contacts/Locations v10
Trial statusRecruiting→Terminated
Reason stoppednot stated→Accrual was slower than anticipated and funding was not extended beyond original contract.
Primary completion dateestimated 2027-12→confirmed 2024-05-15
Completion dateestimated 2030-12→confirmed 2024-05-15
Enrollment targetestimated 16→confirmed 5
Study sitesdetails revised at 1 of 1 site
2025-06-30
2 amendments v8-v9
2 re-verifications since 2024-06-05, no change to tracked fields
2023-05-30
Study Status v7
Primary completion date2025-12→2027-12
Completion date2027-11→2030-12
Show 6 earlier versions
2022-10-25
Study Status v6
Primary completion date2023-12→2025-12
Completion date2025-11→2027-11
2022-09-01
Study Status v5
Primary completion date2023-05-01→2023-12
Completion date2025-03-01→2025-11
2021-09-17
3 amendments v2-v4
3 re-verifications since 2019-09-04, no change to tracked fields
2018-11-05
Not Yet Recruiting→Recruiting Study Identification, Study Status, Sponsor/Collaborators, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2023-03-01→2023-05-01
Start dateestimated 2018-03-01→confirmed 2018-05-08
Study sitesdetails revised at 1 of 1 site
Collaborators+20 characters
Accuray Incorporated
2017-12-13
Original filing
This research is being done to see if a delivery of a single high dose of radiation therapy to a small area of the pituitary gland and pituitary stalk in a highly precise manner may be helpful in reducing intractable pain from bone metastases.
Trial Details
NCT Number NCT03377517
Lead Sponsor Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Collaborators: Accuray Incorporated
Conditions Bone Metastases
Enrollment 5 participants
Start Date 2018-05-08
Primary Completion 2024-05-15 (estimated)
Study Completion 2024-05-15 (estimated)
Updated on ClinicalTrials.gov 2026-09-17