Clinical Trial

Mesenchymal Stromal Cells as Treatment for Digital Ulcers in Systemic Sclerosis

Study acronym: MANUS
Recruiting Phase 1/2
View on ClinicalTrials.gov →
Summary
The MANUS Trial aims to examine the safety, feasibility and potential efficacy of intramuscularly injected allogeneic mesenchymal stromal cells as treatment for digital ulcers of systemic sclerosis.
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2017-07-05; most recent amendment 2025-09-03.
Status change: Not Yet Recruiting → Recruiting 2022-03-21
Status change: Recruiting → Not Yet Recruiting 2018-06-06
Trial Details
NCT Number NCT03211793
Lead Sponsor UMC Utrecht
Collaborators: ZonMw: The Netherlands Organisation for Health Research and Development
Conditions Systemic Sclerosis, Digital Ulcer
Enrollment 20 participants
Start Date 2021-10-06
Primary Completion 2026-11-01 (estimated)
Study Completion 2026-11-01 (estimated)
Updated on ClinicalTrials.gov 2025-09-10