Clinical Trial

Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant

Active, Not Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
This randomized phase III trial studies how well Lactobacillus plantarum works in preventing acute graft versus host disease in children undergoing donor stem cell transplant. Lactobacillus plantarum may help prevent the development of gastrointestinal graft versus host disease in children, adolescents, and young adults undergoing donor stem cell transplant.
Protocol Amendment History 37 amendments
This ClinicalTrials.gov record has been amended 37 times since 2017-02-15; most recent amendment 2025-09-16.
Status change: Completed → Active, Not Recruiting 2023-10-26
Status change: Active, Not Recruiting → Completed 2023-07-12
Status change: Recruiting → Active, Not Recruiting 2022-01-28
Status change: Not Yet Recruiting → Recruiting 2018-05-25
Trial Details
NCT Number NCT03057054
Lead Sponsor Children's Oncology Group
Collaborators: National Cancer Institute (NCI)
Conditions Acute Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm, Leukemia, Lymphoma
Enrollment 173 participants
Start Date 2018-04-30
Primary Completion 2022-06-30 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2025-10-06