Clinical Trial

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

Study acronym: VA-IMPACT
Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood vessel problems.
Protocol Amendment History 48 amendments
This ClinicalTrials.gov record has been amended 48 times since 2016-09-22; most recent amendment 2025-12-12.
Status change: Not Yet Recruiting → Recruiting 2023-04-05
Status change: Active, Not Recruiting → Not Yet Recruiting 2022-04-20
Status change: Recruiting → Active, Not Recruiting 2020-06-16
Status change: Not Yet Recruiting → Recruiting 2019-02-25
Trial Details
NCT Number NCT02915198
Lead Sponsor VA Office of Research and Development
Conditions Prediabetic State, Atherosclerosis, Metformin
Enrollment 7,410 participants
Start Date 2023-04-03
Primary Completion 2029-09-28 (estimated)
Study Completion 2029-09-28 (estimated)
Updated on ClinicalTrials.gov 2025-12-17