Clinical Trial

Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery

Active, Not Recruiting Phase 3
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Summary
This trial will be comparing the combination of amiodarone and NAC (n=122) to amiodarone alone and NAC matched placebo (n=122) to determine the rates with which sustained (lasting \>30 seconds) or clinically significant POAF is reduced in high risk patients within 7 days after major thoracic surgery.
Protocol Amendment History 20 amendments
This ClinicalTrials.gov record has been amended 20 times since 2016-04-22; most recent amendment 2026-05-15.
Status change: Recruiting → Active, Not Recruiting 2020-03-20
Trial Details
NCT Number NCT02750319
Lead Sponsor Memorial Sloan Kettering Cancer Center
Collaborators: Washington University School of Medicine, The Cleveland Clinic, Vanderbilt University School of Medicine
Conditions Thoracic Surgery, Atrial Fibrillation in High Risk Patients
Enrollment 184 participants
Start Date 2016-04
Primary Completion 2027-04 (estimated)
Study Completion 2027-04 (estimated)
Updated on ClinicalTrials.gov 2026-05-19