DISCOVER Study: Microscope-integrated Intraoperative OCT Study

Optical coherence tomography (OCT )provides high resolution information regarding the anatomic structure of the tissues of the eye in a cross-sectional and 3 dimensional view. Much of this information is not able to be visualized by a clinician. Utilizing this information during surgery will allow for the ophthalmic surgeons to better understand how surgical procedures impact the anatomic structure of the eye. In this study an OCT device that has been built into the microscope (rather than mounted on the side or held in the surgeon's hand) and will be utilized to take images at various milestones during surgery to assess feasibility and potential utility of this technology. Since it is built into the microscope, there are potential significant advantages over a separate system including increased efficiency, improved working distance, and the ability to visualize tissue-instrument interactions.

NCT Number	NCT02423213
Lead Sponsor	The Cleveland Clinic Collaborators: National Eye Institute (NEI)
Conditions	Retinal Diseases, Fuchs Endothelial Dystrophy, Macular Hole, Epiretinal Membrane, Retinal Detachment
Enrollment	2,911 participants
Start Date	2014-01
Primary Completion	2026-01 (estimated)
Study Completion	2026-06 (estimated)
Updated on ClinicalTrials.gov	2026-08-03