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Gene Therapy After Frontline Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma

StatusActive, Not Recruiting
PhasePhase 1
Started2015-12-31
View on ClinicalTrials.gov ↗
This pilot clinical trial studies gene therapy after frontline chemotherapy in treating patients with acquired immune deficiency syndrome (AIDS)-related non-Hodgkin lymphoma (NHL). Placing genes for anti-human immunodeficiency virus (HIV) ribonucleic acid (RNA) into stem/progenitor cells may make the body build an immune response to AIDS. Giving the chemotherapy drug busulfan before gene therapy can help gene-modified cells engraft and work better.

Amendment history 2 changes detected by DataLookout

2026-09-02
critical
Primary completion pushed: 2026-08-05 → 2027-07-06
2026-09-02
minor
Completion pushed: 2026-08-05 → 2027-07-06
Trial Details
NCT Number NCT01961063
Lead Sponsor City of Hope Medical Center
Conditions AIDS-related Non-Hodgkin Lymphoma, AIDS-related Plasmablastic Lymphoma, AIDS-related Primary Effusion Lymphoma, HIV Infection
Enrollment 3 participants
Start Date 2015-12-31
Primary Completion 2027-07-06 (estimated)
Study Completion 2027-07-06 (estimated)
Updated on ClinicalTrials.gov 2026-09-01