Clinical Trial

Intensity-Modulated Proton Beam Therapy or Intensity-Modulated Photon Therapy in Treating Patients With Stage III-IVB Oropharyngeal Cancer

Active, Not Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
This randomized phase III trial studies the side effects and how well intensity-modulated proton beam therapy works and compares it to intensity-modulated photon therapy in treating patients with stage III-IVB oropharyngeal cancer. Radiation therapy uses high-energy x-rays, protons, and other types of radiation to kill tumor cells and shrink tumors. It is not yet known whether intensity-modulated proton beam therapy is more effective than intensity-modulated photon therapy in treating oropharyngeal cancer.
Protocol Amendment History 29 amendments
This ClinicalTrials.gov record has been amended 29 times since 2013-07-02; most recent amendment 2026-02-20.
Status change: Recruiting → Active, Not Recruiting 2023-09-01
Status change: Active, Not Recruiting → Recruiting 2022-04-19
Status change: Recruiting → Active, Not Recruiting 2022-02-23
Status change: Not Yet Recruiting → Recruiting 2013-08-26
Trial Details
NCT Number NCT01893307
Lead Sponsor M.D. Anderson Cancer Center
Collaborators: National Cancer Institute (NCI), National Institute of Dental and Craniofacial Research (NIDCR)
Conditions Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7
Enrollment 440 participants
Start Date 2013-08-26
Primary Completion 2031-12-31 (estimated)
Study Completion 2031-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-02-24