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Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

Study acronym: DIAN-TU
StatusActive, Not Recruiting
PhasePhase 2/3
Started2012-12
View on ClinicalTrials.gov ↗
The purpose of this study is to assess the safety, tolerability, biomarker, cognitive and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug slows the rate of progression of cognitive/clinical impairment or improves disease-related biomarkers.

Amendment record

Amended 39 times since 2012-12-31; most recent filed 2026-07-23. Every amendment is listed below.

Dates here are the day the sponsor filed the amendment, not the day ClinicalTrials.gov published it. Version history last read from ClinicalTrials.gov on 2026-08-29.

2026-07-23
Amendment Study Status v39
2026-02-11
Amendment Study Status, Contacts/Locations v38
2025-11-10
Amendment Recruiting→Active, Not Recruiting Study Status, Oversight, Arms and Interventions, Contacts/Locations v37
2025-07-30
Amendment Study Status, Oversight, Contacts/Locations v36
2025-03-31
Amendment Study Status v35
2024-07-01
Amendment Study Status, Study Description, Contacts/Locations v34
2024-05-10
Amendment Study Status, Study Description, Contacts/Locations v33
2023-10-06
Amendment Study Status, Contacts/Locations v32
2023-05-10
Amendment Study Status, Contacts/Locations v31
2023-04-03
Amendment Study Status, Contacts/Locations v30
2022-11-27
Amendment Study Identification, Study Status, Sponsor/Collaborators, Study Description, Arms and Interventions, Contacts/Locations v29
2021-11-01
Amendment Study Status, Study Description, Contacts/Locations v28
2021-06-22
Amendment Study Status, Study Description, Study Design, Arms and Interventions, Outcome Measures, Contacts/Locations v27
2020-10-19
Amendment Completed→Recruiting Study Identification, Study Status, Study Description, Study Design, Arms and Interventions, Outcome Measures, Eligibility, Contacts/Locations, IPDSharing v26
2020-08-03
Amendment Recruiting→Completed Study Identification, Study Status, Sponsor/Collaborators, Study Description, Conditions, Study Design, Arms and Interventions, Outcome Measures, Eligibility, Contacts/Locations v25
2020-03-31
Amendment Study Status, Contacts/Locations, References v24
2019-10-01
Amendment Study Status, Study Description, Contacts/Locations, References v23
2019-06-28
Amendment Active, Not Recruiting→Recruiting Study Status, Contacts/Locations v22
2019-02-26
Amendment Study Identification, Study Status, Sponsor/Collaborators, Study Description, Study Design, Arms and Interventions, Outcome Measures, Eligibility, Contacts/Locations v21
2018-06-05
Amendment Recruiting→Active, Not Recruiting Study Status, Contacts/Locations v20
2018-05-02
Amendment Study Status, Contacts/Locations v19
2018-01-18
Amendment Study Status, Contacts/Locations v18
2017-11-17
Amendment Study Status, Contacts/Locations v17
2017-10-04
Amendment Active, Not Recruiting→Recruiting Study Status, Contacts/Locations v16
2017-08-02
Amendment Study Identification, Study Status, Sponsor/Collaborators, Study Description, Study Design, Arms and Interventions, Outcome Measures, Eligibility, Contacts/Locations v15
2016-10-06
Amendment Study Status v14
2016-06-21
Amendment Study Status, Arms and Interventions v13
2016-03-01
Amendment Study Status v12
2015-11-30
Amendment Recruiting→Active, Not Recruiting Study Status, Contacts/Locations v11
2015-10-07
Amendment Study Status, Contacts/Locations v10
2015-06-10
Amendment Study Identification, Study Status, Sponsor/Collaborators, Study Description, Outcome Measures, Eligibility, Contacts/Locations v9
2015-04-13
Amendment Study Status, Contacts/Locations v8
2014-08-28
Amendment Study Status, Contacts/Locations v7
2014-05-19
Amendment Study Status, Contacts/Locations v6
2014-01-13
Amendment Study Identification, Study Status, Conditions, Contacts/Locations, References v5
2013-10-14
Amendment Study Identification, Study Status, Sponsor/Collaborators v4
2013-07-02
Amendment Study Status v3
2013-04-11
Amendment Study Status, Outcome Measures v2
2013-01-07
Amendment Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
2012-12-31
Original filing
Trial Details
NCT Number NCT01760005
Lead Sponsor Washington University School of Medicine
Collaborators: Eli Lilly and Company, Hoffmann-La Roche, Alzheimer's Association, National Institute on Aging (NIA), Avid Radiopharmaceuticals, Accelerating Medicines Partnership (AMP), Eisai Inc., Janssen, LP
Conditions Alzheimers Disease, Dementia, Alzheimers Disease, Familial
Enrollment 490 participants
Start Date 2012-12
Primary Completion 2028-04 (estimated)
Study Completion 2028-07 (estimated)
Updated on ClinicalTrials.gov 2026-07-27