UK Genetic Prostate Cancer Study: Epidemiology and Molecular Genetics Studies

The UKGPCS was set up to find genetic alterations which occur in patients who have prostate cancer. A man's risk of developing prostate cancer increases if he has a first-degree relative (father or brother) who was diagnosed with prostate cancer at a young age. This is why we are looking for men who are affected at a young age or who have a family history of prostate cancer, since it is more probable that these prostate cancers are due to an inherited genetic cause rather than an environmental cause. We also ask all men who come to the Royal Marsden Hospital to be treated for prostate cancer if they would like to take part in the study so that we can also look to see if we find genetic alterations in older men, and those who do not have a family history of prostate cancer.

NCT Number	NCT01737242
Lead Sponsor	Institute of Cancer Research, United Kingdom Collaborators: Cancer Research UK, Royal Marsden NHS Foundation Trust
Conditions	Prostate Cancer
Enrollment	23,826 participants
Start Date	1993-01
Primary Completion	2023-11 (estimated)
Study Completion	2033-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-12