Radiation Therapy to Treat Musculoskeletal Tumors

StatusActive, Not Recruiting
PhasePhase 2
Started

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Record History

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  1. Re-verified, no change to tracked fieldsv42
  2. Results first posted: Mar 6, 2025
    • Primary endpoints revised (2)
    • Secondary endpoints revised (3)
    v41
  3. Primary completion date changed from estimate of Oct 2024 to Sep 15, 2023
    • Study completion date: Oct 2024 to Oct 2029
    v40
  4. 4 versions Re-verified since Apr 4, 2022, no change to tracked fieldsv36-v39
  5. Primary and study completion dates: Jan 2024 to Oct 2024v35
Show 33 earlier versionsHide 33 earlier versions
  1. 3 versions Re-verified since Nov 15, 2018, no change to tracked fieldsv32-v34
  2. Enrollment target: 199 to 202
    • Primary and study completion dates: Jan 31, 2024 to Jan 2024
    v31
  3. Enrollment target: estimated 280 to confirmed 199v30
  4. Interventions: image-guided radiotherapy (Procedure) to image-guided radiotherapy (Radiation)v29
  5. Primary and study completion dates: Jan 2024 to Jan 31, 2024
    • Start date: Jan 2003 to Jan 10, 2003
    v28
  6. 2 versions Re-verified since Jul 24, 2015, no change to tracked fieldsv26-v27
  7. Trial status: Recruiting to Active, Not Recruiting
    • Site details revised
    v25
  8. Primary completion date: Jan 2019 to Jan 2024v24
  9. Eligibility criteria revised
    • Study description shortened, about 18 words
    v23
  10. Collaborators expanded, about 3 wordsv22
  11. Primary completion date: Oct 2013 to Jan 2019
    • Primary endpoints revised (2)
    • Study completion date: Oct 2028 to Jan 2024
    • Secondary endpoints expanded, about 68 words
    v21
  12. Enrollment target: 210 to 280v20 Show 4 more changesShow less
    • Study completion date: Oct 2017 to Oct 2028
    • Interventions: Delivery of conformal limited margin radiotherapy (Procedure) to image-guided radiotherapy (Procedure)
    • Eligibility criteria expanded, about 38 words
    • Study description expanded, about 57 words
  13. Collaborators shortened, about 3 wordsv19
  14. Primary completion date: Oct 2011 to Oct 2013v18
  15. Re-verified, no change to tracked fieldsv17
  16. Study completion date: Oct 2013 to Oct 2017v16
  17. Eligibility criteria expanded, about 181 words
    • Study description expanded, about 292 words
    v15
  18. Primary completion date: Dec 2010 to Oct 2011
    • Study completion date: Dec 2010 to Oct 2013
    v14
  19. 3 versions Re-verified since Dec 2, 2008, no change to tracked fieldsv11-v13
  20. Primary completion date: Dec 2010v10
  21. Study arms: 0 to 1v9
  22. Enrollment target: 110 to 210v8 Show 4 more changesShow less
    • Study completion date: Dec 2010
    • Interventions: Brachytherapy (Procedure), Radiotherapy (Procedure) to Delivery of conformal limited margin radiotherapy (Procedure)
    • Publications: 1 to 8
    • Collaborators expanded, about 3 words
  23. Primary endpoints revised (2)
    • Eligibility criteria expanded, about 2 words
    v7
  24. Re-verified, no change to tracked fieldsv6
  25. Enrollment target: 100 to 110v5
  26. 3 versions Re-verified since Mar 7, 2006, no change to tracked fieldsv2-v4
  1. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Researchers at St. Jude Children's Research Hospital are looking for more effective ways to deliver radiation therapy to pediatric tumors of the bone and soft tissues. The goal of the study is to improve local control of musculoskeletal tumors with image-guided radiation therapy (IGRT) while minimizing radiation related side effects. IGRT uses computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) images to precisely define tumor location and to carefully plan radiation treatment. This approach allows doctors to deliver highly conformal radiation therapy to the tumor while protecting nearby healthy normal tissues.
Trial Details
NCT Number NCT00186992
Lead Sponsor St. Jude Children's Research Hospital
Collaborators: Lance Armstrong Foundation
Conditions
(from sponsor)		 Sarcoma, Ewing's, Rhabdomyosarcoma, Soft Tissue Sarcoma, Musculoskeletal Tumors
Related terms Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing
Enrollment 202 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov