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Natural History of Thyroid Function Disorders

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Amendment history

The 50 most recent of 355 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Minor

    Re-verified, no change to tracked fields

  2. Minor

    Eligibility criteria expanded, about 22 words

    Study description expanded, about 3 words

    Show what changed: Eligibility criteria
    * INCLUSION CRITERIA: The categories of subjects eligible to participate in this study include: 1. Participants with known or suspected thyroid abnormalities ( [...] TSH- beta subunit, Pax-8, TTF-2, Pit-I, Tg, PDS, and NIS). 2. Participants with thyroid function test (TFT) abnormalities due to: * Non-thyroidal illness * Abnormalities of serum TH binding proteins leading to euthyroid hyperthyroxinemia or hypotriiodothyronemia. * Genetic deficiency of thyroxine-binding globulin (TBG). * Antibodies to mouse immunoglobulins leading to an artifactua [...] pate if the individual meets all of the following criter [...]
    Show what changed: Study description
    [...] issue specimens will be collected for research. Objectives: 1. To understand the pathophysiology and various causes of thyr [...] tion abnormalities (e.g., hyperthyroidism, hypothyroidism). 2. To longitudinally follow the effects of standard therapies for participants with abnormal thyroid functions. 3. To create a repository of clinical data and samples for future research of thyroid disorders. Endpoints: None

  3. Minor

    Study Status

    Re-verified, no change to tracked fields

    v353

  4. Minor

    Study description shortened, about 51 words

    Show what changed: Study description
    Study Description: Participants with known or suspected thyroid function abnormalities (hyperthyroidism, hypothyroidism), areextreme studiediodine deficiency, and treatedinherited forms of hypothyroidism resulting from abnormalities in thisthe protocolexpression of genes coding for the TSH- beta subunit, Pax-8, TTF-2, Pit-I, Tg, PDS, and NIS) and/or with thyroid function tests abnormalities. Participants undergo standard medical/diagnostic procedures such as routine historyexaminations and physical examination, standard endocrine blood and urine tests, a standard TRH test, thyroid nuclear medi [...] [...]

    Study Status, Study Descriptionv352

  5. Minor

    Eligibility criteria expanded, about 61 words

    Study description expanded, about 16 words

    Show what changed: Eligibility criteria
    INCLUSION CRITERIA: The categories of subjects eligible to participate in this study include: PatientsParticipants with known or suspected thyroid abnormalities (e.g. hypothy [...] the TSH- beta subunit, Pax-8, TTF-2, Pit-I, Tg, PDS, and NIS). PatientsParticipants with thyroid function test (TFT) abnormalities due to: Non- [...] lusion criteria for each group of subjects are given below. PatientsParticipants with known or suspected thyroid abnormalities will be eligible to p rticipateparticipate if the individual meets all of the following criteria: Stat [...] thyrotropin (TSH) receptor (TSHR) and the a-subunit o [...]
    Show what changed: Study description
    PatientsParticipants with thyroid function abnormalities (hyperthyroidism, hypothyroidism) are studied and treated in this protocol. PatientsParticipants undergo standard medical/diagnostic procedures such as routine history and physical examination, standard endocrin [...] er standard diagnostic procedures, as clinically indicated. Data from these standard medical/diagnostic procedures will be used for research. The goals of this study are: 1. To understand the pathophysi [...] longitudinally follow the effects of standard therapies for patientsparticipants with abnormal thyroid functionsfunction. 3. To cr [...]

    Study Status, Study Description, Arms and Interventions, Outcome Measures, Eligibility, Contacts/Locationsv351

  6. Minor

    45 amendments

    45 re-verifications since 2025-02-20, no change to tracked fields

    v306-v350

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Participants in this study will be patients diagnosed with or suspected to have a thyroid function disorder. These conditions may include: hypothyroidism, hyperthyroidism, thyroid hormone resistance, Graves' Dermopathy, and thyroid-stimulating hormone (TSH) secreting pituitary adenomas. The main purpose of this study is to further understand the natural history, clinical presentation, and genetics of thyroid function disorders. Many of the tests performed are in the context of standard medical care that is offered to all patients with thyroid function disorders. In addition, blood and tissue samples may be taken for research and genetic studies.
Trial Details
NCT Number NCT00001159
Lead Sponsor National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions Hyperthyroidism, Hypothyroidism, Grave's Disease
Enrollment 2,500 participants
Start Date
Updated on ClinicalTrials.gov