| Detected | Trial | Change |
|---|---|---|
| 2026-06-04 | NCT06136650 A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA)… |
Trial sites expanded: 324 -> 327 locations |
| 2026-05-27 | NCT07548606 A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult… |
overall status: "Recruiting" → "Active Not Recruiting" |
| 2026-05-14 | NCT06979596 A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) |
Trial sites expanded: 52 -> 55 locations |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 3 | |||
| NCT06136624 | Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003) | Prostate Cancer Metastatic | Recruiting |
| NCT06136650 | A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA)… | Metastatic Castration-resistant Prostate Cancer (mCRPC) | Recruiting |
| Phase 2 | |||
| NCT06979596 | A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) | Malignant Neoplasm | Recruiting |
| Phase 1/2 | |||
| NCT06353386 | Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations… | Prostatic Neoplasms, Castration-Resistant | Recruiting |
| NCT06863272 | A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy… | Castration-Resistant Prostatic Cancer | Recruiting |
| Phase 1 | |||
| NCT07548606 | A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult… | Healthy | Active, Not Recruiting |