Disease landscape

Ulcerative Colitis clinical trials

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415 active trials 223 recruiting 36 Phase 3 251 sponsors 65 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 35 of 65 changes on 20 trials

2026-08-11
Trial terminated
Trial terminated: This was a pilot study only. The primary goal of determining feasibility was achieved. Due to logistical issues and a d...
Enrollment reduced: 40 → 19 participants
NCT05561738 Nicotinamide Riboside in Ulcerative Colitis · University of Pittsburgh
2026-08-04
Primary completion pushed: 2027-11-15 → 2028-05-16
Completion pushed: 2027-11-15 → 2028-05-16
NCT06100289 A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's… · Takeda · Phase 3
2026-08-21
Primary completion pushed: 2026-03-31 → 2026-12-31
Completion pushed: 2026-03-31 → 2026-12-31
NCT05316584 A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and… · University of Maryland, Baltimore
2026-08-12
Primary completion pushed: 2026-05 → 2027-11
Primary endpoint(s) modified
Enrollment increased: 162 → 700 participants
Completion pushed: 2026-05 → 2027-11
NCT05867329 Feasibility Pilot Sequential Multiple Assignment Randomized Trial (SMART) for Acute… · Berinstein, Jeffrey · Phase 4
2026-08-12
Primary completion pushed: 2027-12-31 → 2030-12-31
Sponsor changed: PIBD-Net → Erasmus Medical Center
Completion pushed: 2027-12-31 → 2030-12-31
NCT03571373 PIBD-SETQuality: the Inception Cohort and Safety Registry · Erasmus Medical Center
2026-08-08
Primary completion pushed: 2028-03-01 → 2028-08-01
Enrollment reduced: 250 → 216 participants
Sponsor changed: University of California, San Diego → Mayo Clinic
Completion pushed: 2028-06-01 → 2029-02-01
NCT05230173 Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission · Mayo Clinic
2026-08-21
Primary endpoint(s) modified
NCT07758335 The Efficacy of Lactobacillous Probiotic and Trace Elements in the Management of… · National Hepatology & Tropical Medicine Research Institute · Phase 4
2026-08-01
Primary endpoint(s) modified
NCT07700446 Efficacy of Upadacitinib Re-induction Therapy in Patients With Ulcerative Colitis Who… · Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives · Phase 4
2026-08-26
Enrollment reduced: 80 → 66 participants
Recruitment opened
NCT07389824 Efficacy of Acupuncture-Mesalazine Combination Therapy in Ulcerative Colitis. · Qin Yu
2026-08-11
Enrollment reduced: 129 → 84 participants
Enrollment closed, study ongoing
Primary completion pushed: 2026-07 → 2026-08
NCT03843385 Transfer of FRozen Encapsulated Multidonor Stool Filtrate for Active Ulcerative COlitis · Andreas Stallmach · Phase 3
2026-08-07
Enrollment reduced: 12 → 2 participants
NCT05739162 A Study of Endoscopic Sleeve Gastroplasty for Obesity in Ulcerative Colitis · Mayo Clinic
2026-08-28
Enrolling by invitation only
NCT07505030 To Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and… · LyncBio Therapeutics Co., Ltd. · Phase 1
2026-08-19
Recruitment opened
NCT07686081 Study to Evaluate the Efficacy and Safety of Ponesimod (VSP-128) in Patients With… · Vanda Pharmaceuticals · Phase 3
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT06609447 The Efficacy and Safety of Combining Probiotic VSL#3 With Vedolizumab for the Treatment… · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 4
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT05481619 Study of the Effect of Vedolizumab on Intestinal Microecological Changes and Its Efficacy… · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 4
2026-08-18
Enrolling by invitation only
NCT07686757 INSIGHT-IBD Pragmatic Study · Specialty Networks Research. · Phase 4
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07416383 Safety and Efficiency of the Universal CNK-UT009 in Difficult-to-treat Inflammatory Bowel… · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 1
2026-08-08
Trial completed
NCT05626088 A Study in Adults With Inflammatory Bowel Disease (IBD) Receiving Vedolizumab in the… · Takeda
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07487480 A Prospective Observational Study on the Efficacy and Safety of Guselkumab in the… · Second Affiliated Hospital, School of Medicine, Zhejiang University
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07385131 Prophylactic Dexamethasone Before Infliximab in Moderate-to-Severe IBD · Second Affiliated Hospital, School of Medicine, Zhejiang University

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-26 NCT07786389 Seaweed Extract (Fucoidan) for Gut Inflammation in Ulcerative Colitis Allama Iqbal Medical College new Phase 1/2
2026-08-24 NCT07782242 Comaprison of Efficacy and Safety Between Etrasimod vs Mesalazine in Chinese Adults With… Sir Run Run Shaw Hospital new Phase 4
2026-08-19 NCT07773948 ASAPP Study - Topical 5-ASA as Prophylaxis for Pouchitis in Ulcerative Colitis Patients… University Hospital, Linkoeping new Phase 4
2026-08-17 NCT07768254 A Study to Evaluate the Safety, Tolerability, PK and Preliminary Efficacy of HX15001… Helixon Biotechnology (Suzhou) Co., Ltd new Phase 1
2026-08-14 NCT07766733 The Safety and Efficacy of Good Feeling Power® for IBD Patients Good Feeling Products GmbH new
2026-08-12 NCT07760831 A Trial of HRS-7085 Tablets in Patients With Moderate to Severe Active Ulcerative Colitis Jiangsu HengRui Medicine Co., Ltd. new Phase 1
2026-08-11 NCT07758335 The Efficacy of Lactobacillous Probiotic and Trace Elements in the Management of… National Hepatology & Tropical Medicine Research Institute new Phase 4
2026-08-06 NCT07749768 A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ONO-6414… Ono Pharmaceutical Co., Ltd. new Phase 1
2026-08-05 NCT07747155 A Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of PTT-621 in… Pyrotech Therapeutics, Inc. new Phase 2
2026-08-05 NCT07747480 A Sub Study to Investigate the Safety and Tolerability of Aletekitug in Participants With… GlaxoSmithKline new Phase 1

Active trials by phase

Early Phase 1
7
Phase 1
19
Phase 1/2
12
Phase 2
62
Phase 2/3
6
Phase 3
30
Phase 4
37
Not charted: 242 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 415

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07758335 The Efficacy of Lactobacillous Probiotic and Trace Elements in the Management of… National Hepatology & Tropical Medicine Research Institute Recruiting 2026-08-20
NCT06581328 A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the… Takeda Recruiting 2026-08-14
NCT06095128 A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC) Takeda Recruiting 2026-08-12
NCT05867329 Feasibility Pilot Sequential Multiple Assignment Randomized Trial (SMART) for Acute… Berinstein, Jeffrey Recruiting 2026-08-11
NCT07691138 Stopping PPI Therapy in Inactive IBD University of Nottingham Recruiting 2026-07-08
NCT07546097 Comparative Effectiveness of Upadacitinib vs Corticosteroids as First-Line Therapy for… Yongquan Shi Recruiting 2026-06-15
NCT07216014 Interleukin-23 Monoclonal Antibody for Inflammatory Bowel Disease: Efficacy and Safety Sixth Affiliated Hospital, Sun Yat-sen University Recruiting 2026-04-24
NCT07550673 Upadacitinib Versus Infliximab as Second-Line Treatment for Acute Severe Ulcerative… Xijing Hospital of Digestive Diseases Recruiting 2026-04-24
NCT07258771 Upadacitinib Combined With Corticosteroids vs Corticosteroid Monotherapy Induction for… Berinstein, Jeffrey Recruiting 2026-02-02
NCT07303686 De-escalation of Ustekinumab Therapy in Patients With Crohn's Disease and Ulcerative… McGill University Health Centre/Research Institute of the McGill University Health Centre Recruiting 2025-12-26
NCT07235904 Efficacy of Top-down Therapy With Mirikizumab Versus Standard of Care With Azathioprine… University Hospital Schleswig-Holstein Recruiting 2025-12-16
NCT04314375 Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide… Bausch Health Americas, Inc. Recruiting 2025-09-16
NCT05481619 Study of the Effect of Vedolizumab on Intestinal Microecological Changes and Its Efficacy… Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting 2025-07-25
NCT04743518 Impact of Anti-TNF, Vedolizumab and Tofacitinib on Aortic Stiffness, Carotid Intima-media… Centre Hospitalier Universitaire, Amiens Recruiting 2025-05-29
NCT05313620 Effect of Tofacitinib on Coagulation and Platelet Function, and Its Role in… Fundación de Investigación Biomédica - Hospital Universitario de La Princesa Recruiting 2025-03-17
NCT06298461 Bowel Preparation for Colonoscopy Among Individuals With Crohn's and Ulcerative Colitis… University of Manitoba Recruiting 2025-01-08
NCT06609447 The Efficacy and Safety of Combining Probiotic VSL#3 With Vedolizumab for the Treatment… Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting 2024-09-24
NCT06113913 Subcutaneous Infliximab After A Previous Intravenous Dose Optimization Belgian Inflammatory Bowel Disease Research and Development (BIRD) VZW Recruiting 2024-07-26
NCT04999228 Top Down Versus Step up in Pediatric Ulcerative Colitis Children's Hospital of Fudan University Recruiting 2024-02-28
NCT04183608 A Trial COmparing staNdard of Care Versus Treat to Target With telemonitoRing and Patient… Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives Recruiting 2023-05-31
NCT07782242 Comaprison of Efficacy and Safety Between Etrasimod vs Mesalazine in Chinese Adults With… Sir Run Run Shaw Hospital Not Yet Recruiting 2026-08-24
NCT07773948 ASAPP Study - Topical 5-ASA as Prophylaxis for Pouchitis in Ulcerative Colitis Patients… University Hospital, Linkoeping Not Yet Recruiting 2026-08-19
NCT07686757 INSIGHT-IBD Pragmatic Study Specialty Networks Research. Enrolling by Invitation 2026-08-17
NCT07700446 Efficacy of Upadacitinib Re-induction Therapy in Patients With Ulcerative Colitis Who… Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives Not Yet Recruiting 2026-07-31
NCT07665294 Combination CurQD and Vedolizumab in Ulcerative Colitis Ryan C Ungaro Not Yet Recruiting 2026-07-27
See all 415 active Ulcerative Colitis trials with filters →

Top sponsors by active trials in this area

AbbVie (15) · Takeda (11) · Assistance Publique - Hôpitaux de Paris (7) · Assiut University (6) · Eli Lilly and Company (6) · Second Affiliated Hospital, School of Medicine, Zhejiang University (6) · Tanta University (6) · Pfizer (5) · Sixth Affiliated Hospital, Sun Yat-sen University (5) · University of Padova (5)

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