Disease landscape

Lupus clinical trials

Get alerts when Lupus trials change

545 active trials 316 recruiting 45 Phase 3 305 sponsors 66 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 35 of 66 changes on 20 trials

2026-08-06
critical
Withdrawn before enrolling
Trial withdrawn: Decision of Sponsor.
Enrollment reduced: 162 → 0 participants
NCT06984341 A Study to Evaluate the Safety, Tolerability, Cellular Kinetics, Pharmacodynamics, and… · Genentech, Inc. · Phase 1
2026-08-22
notable
Primary completion pushed: 2027-06-22 → 2027-09-21
Trial sites reduced: 156 → 147 locations
NCT05126277 Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC… · Novartis Pharmaceuticals · Phase 3
2026-08-19
critical
Primary completion pushed: 2026-12 → 2027-12
Completion pushed: 2027-12 → 2028-12
NCT03673748 Treatment of Lupus Nephritis With Allogeneic Mesenchymal Stem Cells · Red de Terapia Celular · Phase 2
2026-08-13
critical
Primary completion pushed: 2026-03-31 → 2026-10
Trial status changed: Not Yet Recruiting → Active, Not Recruiting
Completion pushed: 2026-09-20 → 2026-10-31
NCT07203157 HEAL-SLE: Holistic Energy for Alleviating Lupus Symptoms · NYU Langone Health
2026-08-27
critical
Primary endpoint(s) modified
NCT07783711 Predictors of ICU Admission and In-Hospital Mortality in Hospitalized Patients With Lupus… · Khaled Samir Malak Nashed
2026-08-25
critical
Primary endpoint(s) modified
NCT06711146 Safety and Efficacy of Metabolically Armed CD19 CAR-T Cells (Meta10-19) in the Treatment… · Zhejiang University · Early Phase 1
2026-07-31
critical
Primary endpoint(s) modified
Primary completion pushed: 2026-07-01 → 2026-07-31
NCT06947460 CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAH · Beijing GoBroad Hospital · Phase 1/2
2026-08-01
notable
Enrollment reduced: 18 → 16 participants
Enrollment closed, study ongoing
NCT06333483 Obe-cel in Adolescent [Applicable in UK Only] and Adult Severe, Refractory Systemic Lupus… · Autolus Limited · Phase 1
2026-08-18
notable
Sponsor changed: Bristol-Myers Squibb → Beeline Medicines Corporation
NCT04895696 A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in… · Beeline Medicines Corporation · Phase 2
2026-08-19
notable
Enrollment closed, study ongoing
Primary completion pushed: 2026-06 → 2026-09
Trial sites expanded: 82 → 110 locations
Completion pushed: 2026-09 → 2026-12
NCT06559163 A Study of Obexelimab in Patients With Systemic Lupus Erythematosus · Zenas BioPharma (USA), LLC · Phase 2
2026-08-18
notable
Recruitment opened
Trial sites expanded: 0 → 6 locations
NCT07570862 A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis · Fate Therapeutics · Phase 2
2026-08-07
notable
Recruitment opened
NCT07564596 A Phase 1b/2a Study of Budoprutug in Systemic Lupus Erythematosus (SLE) · Climb Bio, Inc. · Phase 1/2
2026-08-05
notable
Recruitment opened
NCT06419205 A Phase 2 Study to Evaluate the Safety, PD, PK, and Clinical Activity of ADX-097 in… · Akebia Therapeutics · Phase 2
2026-08-04
notable
Enrollment closed, study ongoing
NCT07015983 A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in… · Juno Therapeutics, Inc., a Bristol-Myers Squibb Company · Phase 2
2026-08-12
notable
Trial completed
Completion moved earlier: 2026-10-24 → 2026-01-07
NCT06144710 SG301-SC Injection Safety Study in Subjects With Systemic Lupus Erythematosus · Hangzhou Sumgen Biotech Co., Ltd. · Phase 1
2026-08-11
notable
Recruitment opened
Trial sites expanded: 0 → 4 locations
NCT07483346 IASO-782 in Systemic Lupus Erythematosus · Shanghai IASO Biotechnology Co., Ltd · Phase 1
2026-08-09
notable
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT06677801 Immune Cell Subsets in SLE Patients Treated with Telitacicept · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 4
2026-08-08
notable
Recruitment opened
NCT07629583 To Evaluate the Effects of Cevostamab in Participants With Systemic Lupus Erythematosus… · Genentech, Inc. · Phase 1
2026-08-04
notable
Enrollment closed, study ongoing
Trial sites reduced: 54 → 46 locations
NCT05869955 A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe… · Juno Therapeutics, Inc., a Bristol-Myers Squibb Company · Phase 1
2026-08-28
notable
Trial completed
NCT05818254 The HOP-STEP Intervention: Improving Maternal Health in Women With Lupus sIRB · Duke University

Active trials by phase

Early Phase 1
42
Phase 1
114
Phase 1/2
48
Phase 2
64
Phase 2/3
4
Phase 3
41
Phase 4
19
Not charted: 213 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 545

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06594068 Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in… AstraZeneca Recruiting 2026-08-18
NCT07760480 Assessing Residual Inflammation and Macrophage Presence in Lupus Nephritis After 3 Months… Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Recruiting 2026-08-12
NCT07611214 PRESERVE: LUPKYNIS in Combination With Belimumab, Obinutuzumab or Anifrolumab in Patients… Aurinia Pharmaceuticals Inc. Recruiting 2026-08-03
NCT07719140 Childhood-onset Lupus Nephritis Initial Glucocorticoid-dose Harmonization Trial (LIGHT… Peking Union Medical College Hospital Recruiting 2026-07-22
NCT07087912 Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in… University of Sao Paulo General Hospital Recruiting 2026-07-20
NCT07700940 The Efficacy of Empagliflozin on Kidney Functions in Lupus Nephritis Population Ahmed Yehia Ismail Recruiting 2026-07-15
NCT03543839 Trial of Belimumab in Early Lupus Northwell Health Recruiting 2026-06-12
NCT06411249 A Study Describing the Efficacy and Safety of Belimumab Administered in Adult… GlaxoSmithKline Recruiting 2026-06-03
NCT07611747 Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in… Instituto de Investigación Marqués de Valdecilla Recruiting 2026-05-28
NCT07323524 Dapagliflozin in Active Lupus Nephritis Brigham and Women's Hospital Recruiting 2026-05-26
NCT06875960 A Study to Continue the Administration of Deucravacitinib in Participants With Systemic… Bristol-Myers Squibb Recruiting 2026-03-30
NCT07077486 Effects of Telitacicept vs Cyclophosphamide on Lupus Related Interstitial Lung Disease Tongji Hospital Recruiting 2026-01-27
NCT05559671 Safety of the Herpes Zoster Subunit Vaccine in Lupus NYU Langone Health Recruiting 2025-12-26
NCT07225387 Safety and Efficacy of Combination Belimumab and Voclosporin in the Treatment of… NephroNet, Inc. Recruiting 2025-11-06
NCT05207358 Minimizing Glucocorticoid Administration in Patients With Proliferative Lupus Nephritis Institutul Clinic Fundeni Recruiting 2022-03-03
NCT07381465 Efficacy and Safety of IL-1 Inhibitors in Mild to Moderate Systemic Lupus Erythematosus Chinese SLE Treatment And Research Group Active, Not Recruiting 2026-07-15
NCT05879419 Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases University of Sao Paulo General Hospital Active, Not Recruiting 2026-05-04
NCT07035834 SGLT-2 Inhibitors on Albuminuria in Chronic Kidney Disease Patients With Lupus Nephritis… Federico II University Not Yet Recruiting 2025-06-25
NCT06677801 Immune Cell Subsets in SLE Patients Treated with Telitacicept Second Affiliated Hospital, School of Medicine, Zhejiang University Active, Not Recruiting 2024-11-07
Phase 3
NCT06711887 Phase III Extension Study of Efficacy and Safety of Ianalumab With or Without Study… Novartis Pharmaceuticals Recruiting 2026-08-24
NCT06617325 A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants… UCB Biopharma SRL Recruiting 2026-08-21
NCT05799378 Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease NYU Langone Health Recruiting 2026-08-20
NCT07430306 A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in… AstraZeneca Recruiting 2026-08-20
NCT07355218 A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or… EMD Serono Research & Development Institute, Inc. Recruiting 2026-08-17
NCT07332481 A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or… EMD Serono Research & Development Institute, Inc. Recruiting 2026-08-14

Top sponsors by active trials in this area

Get alerts when Lupus trials change
Status changes, date slips, and new sponsor entrants: detected daily, delivered to your inbox.
Start monitoring free