Disease landscape

Hepatocellular Carcinoma (HCC) clinical trials

Get alerts when Hepatocellular Carcinoma (HCC) trials change

241 active trials 122 recruiting 21 Phase 3 165 sponsors 33 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days

2026-08-26
critical
Trial terminated
Trial terminated: The decision has been made to terminate the study due to logistical reasons and not due to any safety concerns.
Primary completion pushed: 2025-12 → 2026-04-09
Enrollment reduced: 43 → 12 participants
Completion pushed: 2025-12 → 2026-04-09
NCT04601428 Hepatic IA Therapy in Stage B or Limited Stage C Hepatoma (HCC) · Koo Foundation Sun Yat-Sen Cancer Center · Early Phase 1
2026-08-18
critical
Primary completion pushed: 2026-10-31 → 2027-09-30
Primary endpoint(s) modified
Recruitment opened
Trial sites expanded: 0 → 7 locations
Completion pushed: 2026-10-31 → 2027-10-31
NCT07209813 GKL-006 Injection Plus TACE Versus TACE Alone in Patients With Unresectable… · Beijing Gene Key Life Technology Co., Ltd · Phase 2
2026-08-21
critical
Primary completion pushed: 2027-12-31 → 2028-12-31
Trial sites expanded: 4 → 8 locations
Completion pushed: 2029-12-31 → 2030-12-31
NCT06773845 Building Evidence for Ablative Internal Radiation Therapy in Localized HCC Beyond the… · Seoul National University Hospital · Phase 2
2026-08-06
critical
Primary endpoint(s) modified
Primary completion moved earlier: 2030-06-28 → 2027-01-31
Trial arms changed: 7 → 9
NCT05176483 Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in… · Exelixis · Phase 1
2026-08-18
critical
Enrollment reduced: 20 → 3 participants
Enrollment closed, study ongoing
Primary completion moved earlier: 2027-10 → 2027-02
Completion moved earlier: 2027-10 → 2027-02
NCT06487559 A Study to Assess the Adverse Events and How Intravenously Infused Livmoniplimab in… · AbbVie · Phase 1
2026-08-26
notable
Enrollment closed, study ongoing
Primary completion moved earlier: 2027-12 → 2026-09
NCT04510740 Liver Cancer Registry Platform · iOMEDICO AG
2026-08-19
notable
Enrolling by invitation only
NCT07620574 Long-Term Extension Study for Participants Previously Enrolled in an Exelixis-Sponsored… · Exelixis · Phase 3
2026-08-20
notable
Recruitment opened
NCT07636785 A Phase 1 and 2 Study of VMD-102 in Hepatocellular Carcinoma and Other Solid Tumors · VM Discovery, Inc. · Phase 1/2
2026-08-26
notable
Recruitment opened
NCT07689175 Adaptive Dosing of Immune Checkpoint Inhibitors for Hepatocellular Carcinoma · University of Texas Southwestern Medical Center · Phase 2
2026-08-09
notable
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07422753 A Prospective, Randomized Study of TACE Combined With Sintilimab, Bevacizumab, and… · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 2
2026-08-09
notable
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07417800 Construction and Clinical Validation of a Predictive Model for Postoperative Adjuvant… · Second Affiliated Hospital, School of Medicine, Zhejiang University
2026-08-27
notable
Enrollment increased: 20 → 42 participants
Trial arms changed: 3 → 5
NCT07551778 Allogeneic NK Cell Therapy Combined With Standard Maintenance Treatment in Advanced Solid… · BOE Technology Group Co., Ltd. · Phase 1/2
2026-08-05
notable
Recruitment opened
NCT07381634 The Safety and Efficacy of Ondansetron in Reducing Immune Checkpoint Inhibitor-Related… · First Affiliated Hospital of Wenzhou Medical University · Phase 2
2026-08-14
notable
Trial status changed: Enrolling by Invitation → Active, Not Recruiting
NCT06618300 Streamlined Resin Y90 Radiation Segmentectomy for Small HCC · UNC Lineberger Comprehensive Cancer Center
2026-07-30
notable
Recruitment opened
NCT07268131 TITAN-HCC: Neoadjuvant and Adjuvant QL1706 With TACE in Resectable Hepatocellular… · Fudan University
2026-08-19
minor
Trial sites expanded: 64 → 67 locations
NCT07291076 A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With… · Bristol-Myers Squibb · Phase 1/2

Active trials by phase

Early Phase 1
4
Phase 1
22
Phase 1/2
25
Phase 2
54
Phase 2/3
6
Phase 3
15
Phase 4
3
Not charted: 112 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 241

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07150624 The Treatment of Liver Injury After Liver Resection With Polyene Phosphatidylcholine Anhui Provincial Hospital Recruiting 2026-05-11
NCT06594744 Endoscopic Variceal Ligation vs Carvedilol for the Prevention of First Esophageal… Taipei Veterans General Hospital, Taiwan Recruiting 2025-02-13
NCT06923176 Effect of Biejia-Ruangan Compound on Survival Rate and Recurrence Rate of Hepatocellular… Zhiyun Yang Not Yet Recruiting 2025-04-11
Phase 3
NCT07322848 DEB-TACE vs cTACE in HCC After TIPS First Affiliated Hospital, Sun Yat-Sen University Recruiting 2026-05-01
NCT07186621 Adjuvant Radiotherapy of Sintilimab Versus TACE for HCC Cancer Institute and Hospital, Chinese Academy of Medical Sciences Recruiting 2025-09-22
NCT06841172 Continuation of First-line Therapy With Radiotherapy Versus Early Switch to Second-line… Shandong Cancer Hospital and Institute Recruiting 2025-08-01
NCT07620574 Long-Term Extension Study for Participants Previously Enrolled in an Exelixis-Sponsored… Exelixis Enrolling by Invitation 2026-08-18
NCT04523493 Phase III Study of Toripalimab(JS001) Combined With Lenvatinib for Advanced HCC Shanghai Junshi Bioscience Co., Ltd. Active, Not Recruiting 2026-07-06
NCT05883644 Durvalumab and Tremelimumab as First Line Treatment in Participants With Advanced… AstraZeneca Active, Not Recruiting 2026-04-30
NCT07537946 Local Consolidation After Sintilimab Plus Lenvatinib for Metastatic Liver Cancer Tongji Hospital Not Yet Recruiting 2026-04-17
NCT07381660 SBRT Versus Surgical Resection for Small HCC Sun Yat-sen University Not Yet Recruiting 2026-02-02
NCT05904886 A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in… Hoffmann-La Roche Active, Not Recruiting 2025-12-31
NCT04639180 A Study to Evaluate Camrelizumab Plus Rivoceranib (Apatinib) as Adjuvant Therapy in… Jiangsu HengRui Medicine Co., Ltd. Active, Not Recruiting 2025-12-30
NCT03755791 Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants… Exelixis Active, Not Recruiting 2025-12-11
NCT06680258 A Study of TPST-1120 With Atezolizumab Plus Bevacizumab in Patients With Unresectable or… Tempest Therapeutics Not Yet Recruiting 2025-09-03
NCT07027436 Radiation Therapy Followed by Durvalumab (MEDI4736) and Tremelimumab And Surgery Versus… Hamilton Health Sciences Corporation Not Yet Recruiting 2025-06-18
NCT06841185 A Study to Compare the Efficacy, Safety, Immunogenicity, and Pharmacokinetic Profile of… Shanghai Henlius Biotech Not Yet Recruiting 2025-02-24
NCT04344158 A Phase III Clinical Trial of AK105 Injection Combined With Anlotinib Hydrochloride… Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Active, Not Recruiting 2025-02-20
Phase 2/3
NCT07490262 A Study to Evaluate the Efficacy and Safety of IBI310 and Sintilimab Combination Therapy… Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD. Recruiting 2026-04-16
NCT07293468 Comparison of SBRT and SIRT With Combination IO for Locally-advanced, Unresectable HCCs… Tuen Mun Hospital Recruiting 2026-04-09
NCT06644937 Single-arm Clinical Trial of TACE in Combination With Icaritin as Adjuvant Therapy After… Zhujiang Hospital Recruiting 2025-09-23
NCT06109272 A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of… AbbVie Recruiting 2025-08-15
NCT07392866 A Clinical Study of SH006 Injection in Combination Therapy Versus Regorafenib in the… Nanjing Sanhome Pharmaceutical, Co., Ltd. Not Yet Recruiting 2026-02-09
NCT06739317 SBRT Combined with Camrelizumab and Apatinib for Conversion Therapy in Patients with… Sun Yat-sen University Not Yet Recruiting 2024-12-18
Phase 2
NCT07689175 Adaptive Dosing of Immune Checkpoint Inhibitors for Hepatocellular Carcinoma University of Texas Southwestern Medical Center Recruiting 2026-08-25

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