Disease landscape

Biliary Tract Cancer clinical trials

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180 active trials 102 recruiting 22 Phase 3 115 sponsors 34 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days

2026-08-12
critical
Primary completion pushed: 2025-06-30 → 2026-12-30
Sponsor changed: Evopoint Biosciences Inc. → Astellas Pharma Global Development, Inc.
Enrollment closed, study ongoing
Completion pushed: 2025-12-31 → 2027-06-30
NCT06792435 XNW27011 Study of Advanced Solid Tumor Subjects Who Failed Standard Therapies. · Astellas Pharma Global Development, Inc. · Phase 1/2
2026-07-30
notable
Primary completion pushed: 2026-08-11 → 2026-11-17
Completion moved earlier: 2027-09-30 → 2027-06-28
NCT06219941 AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2 · AstraZeneca · Phase 2
2026-08-06
critical
Primary completion pushed: 2026-05 → 2027-06
Primary endpoint(s) modified
Completion pushed: 2026-05 → 2027-06
Trial arms changed: 17 → 18
NCT04999761 AB122 Platform Study · Taiho Pharmaceutical Co., Ltd. · Phase 1
2026-08-05
critical
Primary completion pushed: 2026-07 → 2027-09
Completion pushed: 2026-07 → 2027-09
Trial arms changed: 9 → 10
NCT06084481 Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With… · AbbVie · Phase 1
2026-08-18
notable
Primary completion pushed: 2026-07 → 2026-12
NCT06048133 Study of Gemcitabine, Cisplatin, AB680 and AB122 During First Line Treatment of Advanced… · Nataliya Uboha · Phase 2
2026-08-07
critical
Primary completion pushed: 2025-12-31 → 2026-08-12
Primary endpoint(s) modified
Enrollment reduced: 100 → 61 participants
Enrollment closed, study ongoing
Completion pushed: 2026-07-01 → 2027-12-07
NCT07159204 Polymeric Micellar Paclitaxel-Based Combination Therapy for Advanced Biliary Tract Cancer · Peking Union Medical College Hospital · Phase 2
2026-08-01
critical
Enrollment reduced: 117 → 31 participants
Enrollment closed, study ongoing
Trial sites reduced: 18 → 14 locations
NCT06921928 Study for AZD4360 in Participants With Advanced Solid Tumours · AstraZeneca · Phase 1/2
2026-08-20
notable
Enrollment reduced: 24 → 18 participants
Trial completed
Primary completion moved earlier: 2026-05 → 2025-11-17
Completion moved earlier: 2026-05 → 2025-11-17
NCT05220046 Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced… · University of Nebraska · Phase 1
2026-08-25
notable
Enrollment reopened
NCT06084481 Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With… · AbbVie · Phase 1
2026-08-06
notable
Enrollment closed, study ongoing
Trial sites reduced: 17 → 11 locations
NCT07021066 Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of BL-M05D1 in Subjects… · SystImmune Inc. · Phase 1
2026-08-09
notable
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT06139042 Early-stage Detection of LIver, Biliary TRAct and PancReatic Cancers · Second Affiliated Hospital, School of Medicine, Zhejiang University
2026-08-15
notable
Recruitment opened
Trial sites expanded: 1 → 11 locations
NCT07062536 mFOLFOX/mFOLFIRI vs. mFOLFOX in Advanced or Recurrent Biliary Tract Cancer Second-line · Seoul National University Bundang Hospital · Phase 2
2026-08-04
notable
Recruitment resumed after suspension
NCT05285358 Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine… · City of Hope Medical Center · Phase 1
2026-08-22
minor
Trial sites expanded: 174 → 177 locations
NCT07221253 A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of… · AstraZeneca · Phase 3

Active trials by phase

Early Phase 1
1
Phase 1
17
Phase 1/2
20
Phase 2
82
Phase 2/3
6
Phase 3
16
Phase 4
2
Not charted: 36 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 180

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07619235 A Single-arm, Multicenter Clinical Study of Iparomlimab and Toripalimab in Combination… Xianglin Yuan Not Yet Recruiting 2026-06-01
NCT06818773 Inetetamab Plus Chemotherapy ± PD-1/PD-L1 in HER2+ Advanced Biliary Cancer Eastern Hepatobiliary Surgery Hospital Not Yet Recruiting 2025-02-10
Phase 3
NCT07221253 A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of… AstraZeneca Recruiting 2026-08-21
NCT06467357 Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary… AstraZeneca Recruiting 2026-08-19
NCT06622057 D07001 Softgel-Capsules and Capecitabine Combination Therapy in Patients With Advanced… InnoPharmax Inc. Recruiting 2026-07-30
NCT07582315 A Study Comparing BL-B01D1 With Treatment of Physician's Choice in Patients With Locally… Sichuan Baili Pharmaceutical Co., Ltd. Recruiting 2026-07-24
NCT07606599 A Study of BL-M07D1 Versus Physician's Choice of Chemotherapy in Patients With… Sichuan Baili Pharmaceutical Co., Ltd. Recruiting 2026-07-24
NCT07710885 Futibatinib (TAS-120) in Patients With Advanced Biliary Tract Cancer Taiho Pharmaceutical Co., Ltd. Recruiting 2026-07-17
NCT06282575 Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care… Jazz Pharmaceuticals Recruiting 2026-07-14
NCT07265674 A Study to Select a Dose Regimen (Part A) and to Investigate Overall Survival (Part B)… J-Pharma Co., Ltd. Recruiting 2026-07-01
NCT07229625 A Phase III Study of SHR-8068 in Combination With Adebrelimab and Platinum-Containing… Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting 2026-01-28
NCT07062263 Trastuzumab Plus Chemotherapy vs Chemotherapy Alone in First-line HER2 Positive Advanced… Tata Memorial Centre Recruiting 2025-07-14
NCT03875235 Durvalumab or Placebo in Combination With Gemcitabine/Cisplatin in Patients With 1st Line… AstraZeneca Active, Not Recruiting 2026-08-26
NCT07745296 Investigating Precision Medicine in the Adjuvant Setting in Biliary Tract Cancer UNICANCER Not Yet Recruiting 2026-08-04
NCT05771480 Durvalumab With Chemotherapy as First Line Treatment in Patients With Advanced Biliary… AstraZeneca Active, Not Recruiting 2026-07-29
NCT06109779 Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection… AstraZeneca Active, Not Recruiting 2026-07-10
NCT06591520 AK112 Combined With Chemotherapy Versus Durvalumab Combined With Chemotherapy in Advanced… Akeso Active, Not Recruiting 2026-01-21
NCT02170090 Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Standard of Care After… Universitätsklinikum Hamburg-Eppendorf Active, Not Recruiting 2025-03-30
Phase 2/3
NCT05065957 Study of Combination Therapy of D07001-Softgel Capsules and Xeloda/TS-1 in Subjects With… InnoPharmax Inc. Recruiting 2025-04-30
NCT06037980 CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative Chemotherapy Versus… Gruppo Oncologico del Nord-Ovest Recruiting 2025-02-17
NCT07765433 Testing the Addition of Ivonescimab Combined With Standard Chemotherapy Compared to the… ECOG-ACRIN Cancer Research Group Not Yet Recruiting 2026-08-14
NCT05506943 A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable… Compass Therapeutics Active, Not Recruiting 2026-05-07
NCT07437287 Testing Mitazalimab in Combination With Standard Chemotherapy in Immunotherapy Resistant… UNICANCER Not Yet Recruiting 2026-02-27
NCT06662877 Anlotinib Plus Nab-Paclitaxels and S-1 for Patients with Advanced Biliary Tract Cancer As… Sun Yat-sen University Not Yet Recruiting 2024-10-29
Phase 2
NCT07786766 Pemigatinib Plus PD-1 Inhibitor With or Without Chemotherapy in FGFR2… Haitao Zhao, MD Recruiting 2026-08-26

Top sponsors by active trials in this area

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