Disease landscape

Antibody clinical trials

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590 active trials 298 recruiting 58 Phase 3 324 sponsors 79 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 42 of 79 changes on 20 trials

2026-08-21
critical
Trial terminated
Trial terminated: Study logistics or limited study population, as defined by the iclusion/exclusion criteria, leading to a poor recruitment
Primary completion moved earlier: 2028-03 → 2026-07-23
Completion moved earlier: 2029-09 → 2026-07-23
NCT06595563 HER2 Molecular Imaging With 89Zr-trastuzumab PET/CT as a Predictive Biomarker for… · Jules Bordet Institute · Phase 2
2026-08-28
critical
Primary completion pushed: 2025-12 → 2026-12
NCT04794972 A Study of GNC-039, a Tetra-specific Antibody, in Participants With Relapsed/Refractory… · Sichuan Baili Pharmaceutical Co., Ltd. · Phase 1
2026-08-12
critical
Primary completion pushed: 2026-10 → 2027-09
Trial sites reduced: 32 → 19 locations
Completion pushed: 2026-10 → 2027-09
NCT05592626 A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion… · Marengo Therapeutics, Inc. · Phase 1/2
2026-07-31
critical
Primary completion pushed: 2026-06-12 → 2027-02-28
Completion pushed: 2026-06-12 → 2027-02-28
NCT05267626 Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in… · Aulos Bioscience, Inc. · Phase 1/2
2026-07-30
critical
Primary completion pushed: 2025-11 → 2028-05
Primary endpoint(s) modified
Trial sites expanded: 45 → 54 locations
Completion pushed: 2027-11 → 2028-11
NCT03526835 A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors · Merus B.V. · Phase 1/2
2026-08-25
critical
Primary completion pushed: 2026-06-30 → 2027-06-30
Completion pushed: 2027-12-31 → 2028-12-31
NCT05034536 PD-1 Antibody Therapy + Infliximab for Metastatic Melanoma · Massachusetts General Hospital · Phase 2
2026-08-27
critical
Primary completion pushed: 2026-07-21 → 2027-09-10
Completion pushed: 2026-07-21 → 2027-09-10
NCT05204147 Actinium 225 Labeled Anti-CEA Antibody (Ac225-DOTA-M5A) for the Treatment of CEA… · City of Hope Medical Center · Phase 1
2026-08-11
notable
Primary completion pushed: 2027-12 → 2028-06
Enrollment closed, study ongoing
Completion pushed: 2028-12 → 2029-06
NCT04561986 TocIlizumab in Late/Chronic Active Antibody-mediated Rejection in Kidney Transplant… · Vastra Gotaland Region · Phase 3
2026-08-08
critical
Primary completion pushed: 2025-01 → 2029-06
Completion pushed: 2027-01 → 2029-06
NCT05713136 The National Australian HCV Point-of-Care Testing Program - HCV Antibody Testing Minimal… · Kirby Institute
2026-08-13
critical
Primary completion pushed: 2026-06 → 2028-06
Completion pushed: 2026-12 → 2028-12
NCT06263543 Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC · Reshma L. Mahtani, D.O. · Phase 2
2026-08-11
notable
Primary completion pushed: 2026-01-15 → 2026-06-10
NCT06577194 Neoadjuvant Short-Course Radiotherapy Followed by CAPOX Plus PD-1 Antibody and IL-2 in… · The First Affiliated Hospital with Nanjing Medical University · Phase 2
2026-08-06
critical
Primary completion pushed: 2026-07 → 2027-07
Completion pushed: 2026-07 → 2027-07
NCT02502786 Humanized Monoclonal Antibody 3F8 (Hu3F8) With Granulocyte-Macrophage Colony Stimulating… · Memorial Sloan Kettering Cancer Center · Phase 2
2026-08-20
critical
Primary endpoint(s) modified
Enrollment reduced: 263 → 199 participants
NCT04725474 First-in-Human Study of the GDF-15 Neutralizing Antibody Visugromab (CTL-002) in Patients… · CatalYm GmbH · Phase 1/2
2026-08-11
critical
Primary endpoint(s) modified
NCT06918990 Treatment of Antibody-Mediated Rejection (ABMR) With CarBel · National Institute of Allergy and Infectious Diseases (NIAID) · Phase 1
2026-08-19
notable
Phase changed: Phase 1/2 → Phase 2
Recruitment opened
NCT06484153 Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Advanced or… · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Phase 2
2026-08-20
notable
Trial completed
Completion moved earlier: 2026-10-16 → 2026-06-05
NCT06059547 Neoadjuvant Immunotherapy Combined With the Anti-GDF-15 Antibody Visugromab to Treat… · CatalYm GmbH · Phase 2
2026-08-19
notable
Recruitment opened
NCT07545122 A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific… · Context Therapeutics Inc. · Phase 1
2026-07-31
notable
Enrollment closed, study ongoing
NCT06208150 A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and… · Janssen Research & Development, LLC · Phase 3
2026-08-12
notable
Enrollment closed, study ongoing
Trial sites reduced: 55 → 51 locations
NCT06744647 Phase 2 Study of ALXN2030 in Patients With Antibody-Mediated Rejection After Kidney… · Alexion Pharmaceuticals, Inc. · Phase 2
2026-08-04
notable
Completed without a posted recruiting period
Primary completion moved earlier: 2027-07-16 → 2026-03-09
Completion moved earlier: 2027-12-16 → 2026-04-29
NCT07103174 A Study of MG-K10 Humanized Monoclonal Antibody Injection in Subjects With Atopic… · Shanghai Mabgeek Biotech.Co.Ltd · Phase 2

Active trials by phase

Early Phase 1
17
Phase 1
93
Phase 1/2
71
Phase 2
193
Phase 2/3
8
Phase 3
50
Phase 4
19
Not charted: 139 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 590

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06072482 A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis Amgen Recruiting 2026-08-14
NCT07689578 Safety and Efficacy of the Bispecific T-Cell Engager (BiTE) in Kidney Transplant… Turun Song Recruiting 2026-08-05
NCT06722586 Sirolimus Monotherapy in the Treatment of Antiphospholipid Antibody Related… Peking University First Hospital Recruiting 2026-06-30
NCT07216014 Interleukin-23 Monoclonal Antibody for Inflammatory Bowel Disease: Efficacy and Safety Sixth Affiliated Hospital, Sun Yat-sen University Recruiting 2026-04-24
NCT07158814 Safety of RSV Preventive Monoclonal Antibody Duke University Recruiting 2026-03-16
NCT07355699 Application of Orelabrutinib With or Without CD20 Monoclonal Antibody in Previously… Beijing Tongren Hospital Recruiting 2026-01-21
NCT07135427 Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency University of Alabama at Birmingham Recruiting 2025-11-10
NCT05849740 An Exploratory Study of Cluster of Differentiation 38 (CD38) Monoclonal Antibody Combined… Institute of Hematology & Blood Diseases Hospital, China Recruiting 2025-08-05
NCT06930573 A Study of AK112, a PD-1/ VEGF Bispecific Antibody, for Resectable Hepatocellular… The First Affiliated Hospital of Zhengzhou University Recruiting 2025-04-16
NCT07693166 Study of HIV-Exposed Pregnancies and Transplacental Antibody Delivery Following RSVpreF University of British Columbia Not Yet Recruiting 2026-07-09
NCT07653516 Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness Insel Gruppe AG, University Hospital Bern Not Yet Recruiting 2026-07-01
NCT07674368 Rucaparib Monoclonal Antibody for Lorlatinib-Induced Hypercholesterolemia / Mixed Hunan Cancer Hospital Not Yet Recruiting 2026-07-01
NCT04101838 B Cell and Antibody Response to Seasonal Influenza Vaccines in Younger and Older Adults University of Alabama at Birmingham Active, Not Recruiting 2026-05-14
NCT07554014 A Single-center, Prospective, Self-controlled, Observational Real-world Study of the… Second Affiliated Hospital, School of Medicine, Zhejiang University Not Yet Recruiting 2026-04-28
NCT07109297 Study of Monoclonal Antibody Nirsevimab Against Respiratory Syncytial Virus (RSV) in… Sanofi Active, Not Recruiting 2026-03-23
NCT07051070 Efficacy and Safety of Rituximab in the Treatment of Anti-Vimentin Antibody-associated… Xuanwu Hospital, Beijing Not Yet Recruiting 2025-07-03
NCT06825312 Immunogenicity, Safety, and Antibody Persistence of Different Immunization Strategies… Liaoning Chengda Biotechnology CO., LTD Active, Not Recruiting 2025-03-11
NCT06678373 Monitoring JE Antibody Levels in Healthy Populations and Immunization Strategy in… Liaoning Chengda Biotechnology CO., LTD Active, Not Recruiting 2024-12-13
NCT06653907 Levothyroxine Intervention in Pregnant Women with TSH (2.5 MIU/L-upper Limit of Reference… Yang ZHANG Not Yet Recruiting 2024-10-23
Phase 3
NCT06152575 MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People… Pfizer Recruiting 2026-08-24
NCT05199688 A Study To Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, And… Hoffmann-La Roche Recruiting 2026-08-11
NCT07258511 A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3… Janssen Research & Development, LLC Recruiting 2026-07-31
NCT06182774 Fixed Duration vs Continuous Anti-CD38 Antibody Therapy Among Transplant Ineligible Older… Canadian Cancer Trials Group Recruiting 2026-07-14
NCT07689630 Anti-CD25 Monoclonal Antibody for Prevention of Acute GVHD After Haploidentical HSCT Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Recruiting 2026-07-08
NCT06794086 SBRT + PD-1 Monoclonal Antibody in Unresectable Colorectal Liver Metastases Jun Huang Recruiting 2026-06-30

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