AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Study acronym: AMAZE 6
StatusRecruiting
PhasePhase 3
Started

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Record History

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  1. Study sites revised (81)v5
  2. Study sites revised (81)v4
  3. Site details revised at 2 of 81 sitesv3
  4. Recruitment openedv2 Show 4 more changesShow less
    • Primary completion pushed from Jun 19, 2028 to Aug 14, 2028
    • Trial sites expanded: 78 → 81 locations
    • Study completion date: Jul 17, 2028 to Aug 14, 2028
    • Start date changed from estimate of Apr 13, 2026 to Apr 20, 2026
  5. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Novo Nordisk
269 trials monitored
See 14 trials at risk
Obesity
3,903 trials monitored
See 160 trials at risk
This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Trial Details
NCT Number NCT07509307
Lead Sponsor Novo Nordisk A/S
Conditions
(from sponsor)		 Obesity, Overweight, Osteoarthritis, Knee
Related terms Obesity, Osteoarthritis, Knee, Overweight
Enrollment 400 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov