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CIPN-NEXTNCT07913958

The Effect of Aerobic and Resistance Training With and Without Neurodynamic Exercises on Chemotherapy-induced Peripheral Neuropathy Symptoms and Associated Neuro-immune Mechanisms

StatusNot Yet Recruiting
PhaseNot applicable
Primary completion (estimated)
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Record History

All 1 version: 1 with changes below.

  1. Study First Submitted

Endpoints

Primary

Chemotherapy-induced peripheral neuropathy (CIPN) sensory symptom severity
Timeframe: at 12 weeks follow-up

Secondary (15)

Chemotherapy-induced peripheral neuropathy (CIPN) sensory, motor and autonomic symptom severity
Chemotherapy-induced peripheral neuropathy (CIPN) signs
Pain severity hands and feet
General pain location and interference
Physical functioning
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Self-reported physical activity
Objective physical activity
Fatigue
Sleep disturbance
Depression
Anxiety
Social participation
Support
Cognitive function
Health-related quality of life

Arms and interventions

Exercise program 1: aerobic + resistance trainingActive comparator

Participants receive advice on physical activity and an activity tracker to monitor physical activity levels, in addition they receive a 12-week individually tailored exercise program consisting of aerobic and resistance training.

Exercise program 2: aerobic + resistance training combined with neurodynamic exercisesExperimental

Participants receive advice on physical activity and an activity tracker to monitor physical activity levels, in addition they receive a 12-week individually tailored exercise program consisting of aerobic training, resistance training and neurodynamic exercises. Neurodynamic exercises are integrated within the exercise program and are progressively adapted according to symptom response.

Wait-list controlNo intervention

Participants receive advice on physical activity and an activity tracker to monitor physical activity levels. After 12 weeks, participants are offered the opportunity to participate in Exercise Program 1.

Behavioral: Exercise program 1: aerobic + resistance training, Exercise program 2: aerobic + resistance training combined with neurodynamic exercises

Sites

2 sites in 1 country