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NCT07897591

Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis

StatusRecruiting
PhaseNot applicable
Primary completion (estimated)
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Record History

All 1 version: 1 with changes below.

  1. Study First Submitted

Endpoints

Primary

Post-operative Pain Score
Timeframe: 6, 12, 24, 48, and 72 hours postoperatively

Secondary (1)

Reduction in Endotoxin Levels

Arms and interventions

Sodium Hypochlorite 2.5% Without ActivationActive comparator

Participants will receive root canal irrigation using 2.5% sodium hypochlorite during instrumentation without ultrasonic activation

Sodium Hypochlorite 2.5% With Ultrasonic ActivationActive comparator

Participants will receive root canal irrigation using 2.5% sodium hypochlorite during instrumentation followed by ultrasonic activation using the Ultra X device.

Metronidazole 0.5% Without ActivationExperimental

Participants will receive root canal irrigation using 0.5% metronidazole during instrumentation without ultrasonic activation.

Metronidazole 0.5% With Ultrasonic ActivationExperimental

Participants will receive root canal irrigation using 0.5% metronidazole during instrumentation followed by ultrasonic activation using the Ultra X device.

Nano-formulated Metronidazole 0.5% Without ActivationExperimental

Participants will receive root canal irrigation using 0.5% nano-formulated metronidazole during instrumentation without ultrasonic activation

Nano-formulated Metronidazole 0.5% With Ultrasonic ActivationExperimental

Participants will receive root canal irrigation using 0.5% nano-formulated metronidazole during instrumentation followed by ultrasonic activation using the Ultra X device.

Drugs: Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5%

Devices: Ultra X Ultrasonic Activation

Sites

1 site in 1 country

  • Faculty of Dentistry, October 6 UniversityGiza, Giza Governorate, Egypt