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Epigenetic Clock to Predict Ovarian Aging and Live Birth in ART

Study acronym: ARTCLOCK
StatusCompleted
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

  1. Study First Submitted
Epigenetic clocks based on DNA methylation estimate biological age and are associated with age-related conditions, but they have not been validated for female fertility. This prospective, multicenter, observational, non-profit cohort study investigated whether epigenetic age, estimated from peripheral blood DNA methylation, differs between women undergoing in vitro fertilization (IVF/ICSI) who achieve a live birth and those who do not. In a predefined subgroup of 30 women under 40 years of age, epigenetic age was also assessed after ovarian stimulation. Participation did not change clinical management.
Trial Details
NCT Number NCT07875140
Lead Sponsor Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Collaborators: Policlinico Umberto I Roma, University of Milan
Conditions
(from sponsor)		 Infertility Assisted Reproductive Technology, Ovarian Aging
Enrollment 400 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov