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Metabolic and Immunologic Biomarkers in Chronic Rhinosinusitis With Nasal Polyps

StatusRecruiting
PhaseNot specified
Started
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Record History

  1. Study First Submitted
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease of the sinonasal mucosa whose metabolic and immunologic mechanisms are incompletely understood. This prospective case-control study aims to characterize metabolic and immunologic biomarkers in patients with CRSwNP compared with control subjects. Nasal tissue and peripheral blood samples will be analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for free amino acid and carnitine/acylcarnitine profiles, and levels of interleukin-40 (IL-40), interleukin-6 (IL-6), and hypoxia-inducible factor-1 alpha (HIF-1α) will be measured by ELISA. The findings are expected to contribute to understanding disease pathogenesis and to identifying potential diagnostic biomarkers and therapeutic targets.
Trial Details
NCT Number NCT07860411
Lead Sponsor Harran University
Conditions
(from sponsor)		 Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Nasal Polyps
Related terms Nasal Polyps
Enrollment 80 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov