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Prevent Wheeze Trial

Study acronym: PRE-WHEE
StatusNot Yet Recruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Study First Submitted
This trial investigates whether a single dose of dexamethasone will prevent recurrent wheezing in children at high-risk for asthma admitted to hospital with a lower respiratory tract infection (LRTI). Eligible children will be identified and enrolled upon hospital admission or during hospitalisation and allocated to receive either dexamethasone 0.6 mg/kilogram body weight or the similar number of placebo tablets (allocation ratio 1:1). The follow-up is 12 months and comprises scheduled on-site examinations by physician and study nurse, scheduled phone contacts, and registrations of new LRTI-episodes (if any). Nasopharyngeal swabs and blood will be collected at specified visits. The children will be invited to a follow-up study at school age for lung function assessments.
Trial Details
NCT Number NCT07858773
Lead Sponsor Norwegian University of Science and Technology
Collaborators: Dhulikhel Hospital, University of Witwatersrand, South Africa
Conditions
(from sponsor)		 Lower Respiratory Tract Infection (LRTI), Recurrent Wheezing
Related terms Asthma, Respiratory Sounds
Enrollment 486 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov