Skip to content
DataLookout
Start free
Menu

NCT07853079

Motivational Intervention for Patients With Schizophrenia

StatusNot Yet Recruiting
PhaseNot applicable
Primary completion (estimated)
Track this trial

Free. We email you which fields changed when ClinicalTrials.gov updates this record.

Record History

All 1 version: 1 with changes below.

  1. Study First Submitted

Endpoints

Primary

Apathy score on the Brief Negative Symptom Scale (BNSS)
Timeframe: Baseline, and within 2 weeks after the end of the 8-week intervention or treatment-as-usual period

Secondary (8)

Ventral striatal activation during reward anticipation
Association between change in ventral striatal activation and change in apathy
Fronto-limbic connectivity during emotion processing
Prefrontal activation and fronto-striatal connectivity during social decision-making
Resting-state functional connectivity
Show 3 moreShow less
Positive symptoms on the Positive and Negative Syndrome Scale (PANSS)
Self-rated negative symptoms (Self-evaluation of Negative Symptoms, SNS)
Cognition (Brief Assessment of Cognition in Schizophrenia, BACS)

Arms and interventions

Positive Emotions Program for Schizophrenia (PEPS) group psychotherapyExperimental

Patients receive the Positive Emotions Program for Schizophrenia (PEPS) in addition to their usual outpatient care. PEPS consists of eight weekly 1-hour group sessions led by a psychologist. Sessions train skills to anticipate, savour, express and share positive emotions, and to challenge defeatist beliefs, with home exercises between sessions.

Treatment as usual (TAU)No intervention

Patients continue their usual outpatient care for 8 weeks without PEPS. Usual care includes regular follow-up by their psychiatrist and nurse, antipsychotic medication, and non-specific group activities. None of these specifically targets negative symptoms. Patients are offered PEPS after completing the study.

Behavioral: Positive Emotion Program for Schizophrenia (PEPS), a psychotherapeutic intervention,