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Sequential vs. Combined Letrozole and Methotrexate for Tubal Ectopic Pregnancy.

StatusActive, Not Recruiting
PhasePhase 2/3
Started
View on ClinicalTrials.gov ↗

Record History

  1. Study First Submitted
Benha University
124 trials monitored
See 3 trials at risk
This study evaluates two medical strategies designed to minimize surgical intervention and reduce methotrexate (MTX) exposure in women with undisturbed tubal ectopic pregnancy (TEP). Participants with undisturbed TEP and pre-treatment serum $\\beta$-hCG levels $\<3500\\text{ IU/L}$ are randomized to receive either a sequential regimen (initial letrozole monotherapy, reserving MTX only for treatment non-responders) or a combined regimen (simultaneous letrozole and single-dose MTX from day one). The study aims to compare the overall success rate of resolving TEP without emergency surgery, as well as the ability of the sequential approach to avoid MTX administration altogether.
Trial Details
NCT Number NCT07842796
Lead Sponsor Benha University
Conditions
(from sponsor)		 Ectopic Pregnancy
Related terms Pregnancy, Ectopic
Enrollment 144 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov