Microsurgical Resection Combined With Photodynamic Therapy for Recurrent Glioblastoma

Patients receive hematoporphyrin injection (Hiporfin) 5 mg/kg intravenously in 250 mL normal saline under light protection 48-72 hours before surgery, after a negative skin test. Standard craniotomy with microsurgical resection of recurrent glioblastoma is performed, followed by intraoperative irradiation of the resection cavity with a 630-nm semiconductor laser (1 W, 120-150 mW/cm2, 150-200 J/cm2). Dexamethasone 10 mg IV daily for 3 days preoperatively. Postoperative whole-body light protection for 72 hours and avoidance of direct sunlight for 30 days.