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The Effect of High-Intensity Short-Duration Exercise Versus Moderate-Intensity High-Volume Exercise on Glucose Control

StatusNot Yet Recruiting
PhaseNot applicable
Started2026-09-15
View on ClinicalTrials.gov ↗
This study will be conducted as a prospective, randomized crossover trial evaluating non-diabetic and pre-diabetic adults ($n=12$) continuously monitored with Dexcom G7 continuous glucose monitors over an 11-day period. Participants will complete two distinct exercise protocols in a randomized sequence: five consecutive days of Zone 2 aerobic exercise and a single session of high-intensity interval training (HIIT). Primary outcome metrics will focus on mean glucose levels and time in range (TIR, defined as $\\le 120\\text{ mg/dL}$) recorded throughout each active exercise block and its associated recovery window. To evaluate the comparative efficacy of the two modalities, paired within-subject differences will be statistically analyzed against pre-specified non-inferiority margins set at $3\\text{ mg/dL}$ for mean glucose, as well as a primary $3$-point and secondary $5$-point margin for time in range.
Trial Details
NCT Number NCT07829042
Lead Sponsor University of California, San Francisco
Conditions Glucose Control
Enrollment 12 participants
Start Date 2026-09-15
Primary Completion 2026-10-15 (estimated)
Study Completion 2026-10-20 (estimated)
Updated on ClinicalTrials.gov 2026-09-22