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The Effect of Chronic ssrı/snrı Antidepressant Treatment on Propofol Consumption in Elective Spine Surgery

StatusNot Yet Recruiting
PhaseNot specified
Started
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Record History

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  1. Study title revised
    • Eligibility criteria shortened, about 2 words
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this observational study is to learn whether long-term use of selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants is related to the amount of propofol needed during planned spine surgery. Propofol is a medicine given through a vein to produce and maintain anesthesia. The main questions this study aims to answer are: * Do patients who regularly take an SSRI or SNRI need a different total amount of propofol during surgery than patients who do not take these medicines? * Are there differences in propofol and remifentanil use, depth of anesthesia, vital signs, or recovery time between the study groups? The study will include 216 adults undergoing planned spine surgery. Researchers will compare 108 participants who regularly take an SSRI or SNRI with 108 participants who do not take these medicines. All participants will receive routine anesthesia care. The study will not start, stop, or change any antidepressant treatment, and participants will not be randomly assigned to a group. Researchers will record the amount of propofol and remifentanil used during surgery, blood pressure, heart rate, oxygen level, depth of anesthesia, and recovery time.
Trial Details
NCT Number NCT07822295
Lead Sponsor Kocaeli City Hospital
Conditions
(from sponsor)		 Chronic SSRI/SNRI Use and Intraoperative Propofol Requirements
Enrollment 216 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov