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The Relationship Between Novel Virological Indicators and Treatment With Different Nucleotide Analogues and the Prognosis of HBV-ACLF Patients

StatusCompleted
PhaseNot specified
Started2022-02-01
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197 trials monitored
See 2 trials at risk
This is an observational study. This study mainly explores the dynamic changes of HBV RNA and HBcrAg during the treatment of HBV-ACLF, as well as the safety of entecavir (ETV), tenofovir alafenamide (TAF) and tenofovir amibufenamide (TMF) during the treatment process, and evaluates the differences in patient prognosis among the three drugs.
Trial Details
NCT Number NCT07815418
Lead Sponsor Tongji Hospital
Conditions Acute-on-Chronic Liver Failure (ACLF), hepatitisB, Treatment
Enrollment 235 participants
Start Date 2022-02-01
Primary Completion 2024-04-01 (estimated)
Study Completion 2026-07-01 (estimated)
Updated on ClinicalTrials.gov 2026-09-11