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Quality of Recovery at Days 5-7 After Ankle Surgery: a Multicenter Study in Seine-Maritime

Study acronym: QoR - CHEVILLE
StatusNot Yet Recruiting
PhaseNot specified
Started2026-10-01
View on ClinicalTrials.gov ↗
Ankle fractures are among the most common fractures in trauma care, with an estimated annual incidence of 100 to 150 per 100,000 inhabitants and a marked increase after age 40. These fractures affect both young individuals-typically following high-energy trauma-and older adults-often resulting from low-energy falls-with a female predominance in the latter group. Surgical fixation (for bi-malleolar, tri-malleolar, or unstable fractures) remains the gold standard for displaced or unstable injuries, requiring appropriate anesthetic management. Ankle surgery is recognized as one of the most painful orthopedic procedures in the postoperative period, due to extensive local innervation and significant tissue edema. Despite advances in multimodal analgesia protocols-incorporating paracetamol, nefopam, non-steroidal anti-inflammatory drugs (NSAIDs), and corticosteroids-postoperative pain remains inadequately controlled in a significant proportion of patients. Persistent pain after discharge is associated with a twofold increase in the risk of emergency department visits or hospital readmission, highlighting the clinical and socioeconomic impact of insufficient postoperative analgesia. Furthermore, postoperative pain following ankle surgery is not limited to a nociceptive component. Intraoperative nerve injuries (such as traction neuropraxia or compression caused by edema or fixation hardware) can induce a neuropathic component, which is frequently underestimated in clinical practice.
Trial Details
NCT Number NCT07814937
Lead Sponsor University Hospital, Rouen
Conditions Ankle Surgery
Enrollment 260 participants
Start Date 2026-10-01
Primary Completion 2027-11-01 (estimated)
Study Completion 2028-05-03 (estimated)
Updated on ClinicalTrials.gov 2026-09-11