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Impact of Dexmedetomidine Versus Propofol on Intracranial Pressure in Adult Traumatic Brain Injury Patients: Randomized Controlled Double-Blind Trial

StatusNot Yet Recruiting
PhasePhase 4
Started2026-10-01
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1,604 trials monitored
See 18 trials at risk
To investigate whether dexmedetomidine or propofol is more effective in controlling intracranial pressure (ICP) (assessed via optic nerve sheath diameter "ONSD" as a primary outcome) and which is more effective in suppressing lipid peroxidation (measured via malondialdehyde "MDA" as a secondary outcome). This double-blind randomized controlled trial aims to bridge this research gap by evaluating the biochemical neuroprotective efficacy alongside the clinical outcomes of both agents in TBI patients.
Trial Details
NCT Number NCT07807579
Lead Sponsor Assiut University
Conditions Traumatic Brain Injuries
Enrollment 80 participants
Start Date 2026-10-01
Primary Completion 2027-11-01 (estimated)
Study Completion 2028-01-01 (estimated)
Updated on ClinicalTrials.gov 2026-09-10