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Efficacy and Safety of RFA vs MWA for Treatment of Large Benign Thyroid Nodules, RCT

StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated September 21, 2026 (before its estimated October 1, 2026 completion). Its status may not reflect the trial's current state.
Trial flagged as At Risk
Primary endpoint removed 2 → 1 primary endpoints
See other at-risk trials from The University of Hong Kong

Record History

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  1. Primary endpoint(s) modified Show 8 more changesShow less
    • Enrollment closed, study ongoing
    • Final enrollment: 50 participants (planned 25)
    • Primary completion moved earlier from Nov 1, 2026 to Oct 1, 2026
    • Study completion moved earlier from Jun 30, 2027 to Mar 30, 2027
    • Eligibility criteria revised
    • Secondary endpoints: 3 to 5
    • Study description shortened, about 253 words
    • Site details revised
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
We conduct a multi-institutional randomized control trial of RFA and MWA for the primary treatment of large, benign nodules. Adult patients \>/=18 years of age who have a solitary thyroid nodule ≥20ml in volume who presents to 1) Columbia University, NY or 2) Queen Mary Hospital, Hong Kong for consultation will be eligible for enrollment in the study. They will need either a) two benign fine needle biopsies, with the most recent biopsy performed within 1 year of enrollment in study or b) one benign fine needle biopsy and low suspicion characteristics on ultrasound. Both functional and non-functional nodules are eligible. Patients will be randomly assigned to either treatment arm a) RFA or treatment arm b) MWA according to a pre-generated block randomization list.
Trial Details
NCT Number NCT07804862
Lead Sponsor The University of Hong Kong
Collaborators: Columbia University
Conditions
(from sponsor)		 Ablation Techniques, RFA, Ablation Treatment, Benign Thyroid Nodules, Local Anaesthesia
Enrollment 50 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov