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Protocolised Natriuresis-Guided Decongestion at Different Diuretic Intensities in Acute Heart Failure

Study acronym: DESTINaTE-AHF
StatusCompleted
PhaseNot applicable
Started2026-01-01
View on ClinicalTrials.gov ↗
The goal of this clinical trial is to learn how different doses of a water-removing medicine (diuretic) work in adults admitted to hospital with acute heart failure. It will also assess the safety of these treatment approaches. The main questions this study aims to answer are: Does starting with a higher or lower dose of diuretic affect how much sodium and urine the body removes during the first 24 hours? Are there differences in side effects or short-term health outcomes between the treatment approaches? Researchers will compare two treatment approaches that use urine sodium and urine output to guide diuretic treatment with standard care. Participants will receive intravenous diuretic treatment and have their urine sodium, urine output, symptoms, blood tests, and clinical outcomes assessed.
Trial Details
NCT Number NCT07804654
Lead Sponsor Universiti Teknologi Mara
Conditions Acute Heart Failure (AHF)
Enrollment 109 participants
Start Date 2026-01-01
Primary Completion 2026-07-01 (estimated)
Study Completion 2026-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-09-04