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Magnetic Resonance Imaging of Cerebral Connectivity and Volume in Neurodegeneration and Glaucoma

Name: Magnetic Resonance Imaging of Cerebral Connectivity and Volume in Neurodegeneration and Glaucoma — clinical trial record (NCT07802769)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: EVOLUTION

StatusRecruiting

PhaseNot applicable

SponsorUniversity Hospital, Bordeaux

Started2026-08-28

View on ClinicalTrials.gov ↗

University Hospital, Bordeaux

458 trials monitored

See 6 trials at risk

The EVOLUTION is a 10-year extension of the ENVOL study. It seeks to compare the evolution of structural and functional connectivity (Hub Disruption Index) and cerebral volume on 3T MRI of the brain in glaucoma patients and matched controls. The study aims to examine the hypothesis that glaucomatous optic neuropathy is not limited solely to the visual pathway, but rather is associated with a broader degeneration of the central nervous system.

Trial Details

NCT Number	NCT07802769
Lead Sponsor	University Hospital, Bordeaux
Conditions	Glaucoma
Enrollment	100 participants
Start Date	2026-08-28
Primary Completion	2027-05 (estimated)
Study Completion	2027-05 (estimated)
Updated on ClinicalTrials.gov	2026-09-03