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Postprandial Glucose Kinetics After Carbohydrate Restriction

StatusCompleted
PhaseNot applicable
Started2019-11-01
View on ClinicalTrials.gov ↗
The goal of this study is to test whether a low-carbohydrate diet (LCD), comparred with a Mediterranean diet (MED) producing similar weight loss, differentially affects fasting and postprandial glucose metabolism in individuals with overweight and dysglycemia. The main questions it aims to answer are: * Is oral glucose absorption delayed or reduced after chronic carbohydrate restriction? * Is insulin sensitivity differentially affected? Participants will follow 4 weeks of LCD and 4 weeks of MED, in a random order, separated by a 4-week washout. After each intervention, participants will undergo a dual-tracer 75-g oral glucose tolerance test.
Trial Details
NCT Number NCT07802275
Lead Sponsor Azienda Ospedaliero, Universitaria Pisana
Conditions Prediabetes, Obesity & Overweight, Diet Interventions, Carbohydrate Metabolism
Enrollment 29 participants
Start Date 2019-11-01
Primary Completion 2024-03-30 (estimated)
Study Completion 2026-08-30 (estimated)
Updated on ClinicalTrials.gov 2026-09-03